Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 2005; 93(03): 399-400
DOI: 10.1055/s-0037-1616568
DOI: 10.1055/s-0037-1616568
Editorial Focus
A spoonful of sugar helps the medicine go down… but platelet eNOS activity go up!
Authors
Further Information
Publication History
Received
27 January 2005
Accepted after revision
28 January 2005
Publication Date:
14 December 2017 (online)
-
References
- 1 Radomski M. et al. An L-arginine/nitric oxide pathway in human platelets regulates aggregation. Proc Natl Acad Sci USA 1990; 87: 5193-7.
- 2 Freedman JE. et al. Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res 1999; 84: 1416-21.
- 3 Massucco P, Mattiello L, Russo I. et al. High glucose rapidly activates the nitric oxide/cyclic nucleotide pathway in human platelets via an osmotic mechanism. Thromb Haemost 2005; 93: 517-26.
- 4 Freedman JE. α -Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release. FASEB J 2000; 14: 2377-9.
- 5 Assert R. et al. Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro. Diabetologia 2001; 44: 188-95.
- 6 Nolte C. et al. Synergistic phosphorylation of the focal adhesion-associated vasodilator-stimulated phosphoprotein in intact human platelets in response to cGMP-and cAMP-elevating platelet inhibitors. Biochem Pharmacol 1994; 48: 1569-75.
- 7 Manns JM, Brenna KJ, Colman RW. et al. Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases. Thromb Haemost 2002; 87: 873-9.
- 8 Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 2003; 284: R1-R12.
- 9 Guzik TJ. et al. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 2002; 105: 1656-62.
- 10 Hirata K, Kuroda R, Sakoda T. et al. Inhibition of endothelial nitric oxide synthase activity by protein kinase C. Hypertension 1995; 25: 180-5.
- 11 Tsukahara H. et al. Continuous monitoring of nitric oxide release from human umbilical vein endothelial cells. Biochem Biophys Res Commun 1993; 193: 722
- 12 Davda RK, Chandler LJ, Guzman NJ. Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase. Eur J Pharmacol 1994; 266: 237-44.
- 13 Ayajiki K. et al. Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells. Circ Res 1996; 78: 750-8.
- 14 Harris MB, Ju H, Venema VJ. et al. Reciprocal phosphorylation and regulation of the endothelial nitric oxide synthase in response to bradykinin stimulation. J Biol Chem 2001; 19: 16587-91.
- 15 Fleming I. et al. Phosphorylation of Thr495 regulates Ca2+/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res 2001; 88: e68-e75.
- 16 Michell BJ. et al. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 2001; 276: 17625-8.
- 17 Lenasi H, Kohlstedt K, Fichtlscherer B. et al. Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495. Cardiovasc Res 2003; 59: 844-53.
- 18 Laight DW, Kaw AV, Carrier MJ. et al. Pharmacological modulation of endothelial function by insulin in the rat aorta. J Pharm Pharmacol 1998; 50: 1117-20.
- 19 Lembo G. et al. Insulin enhances endothelial α 2-adrenergic vasorelaxation by a pertussis toxin mechanism. Hypertension 1997; 30: 1128-34.
- 20 Fleming I, Schulz C, Fichtlscherer B. et al. AMPactivated protein kinase (AMPK) regulates the insulininduced activation of the nitric oxide synthase in human platelets. Thromb Haemost 2003; 90: 863-7.
- 21 Randriamboavonjy V, Schrader J, Busse R. et al. Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway. J Exp Med 2004; 199: 347-56.
- 22 Lantoine F, Brunnet A, Bedioui F. et al. Direct measurement of nitric oxide production in platelets: relationship with cytosolic Ca2+ concentration. Biochem Biophys Res Commun 1995; 215: 842-8.
- 23 Rosado JA, Sage SO. Protein kinase C activates non-capacitative calcium entry in human platelets. J Physiol 2000; 529: 159-69.
- 24 Li Z, Xi X, Gu M. et al. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 2003; 112: 77-86.
- 25 Li Z, Zhang G, Marjanovic JA. et al. A platelet secretion pathway mediated by cGMP-dependent protein kinase. J Biol Chem 2004; 279: 42469-75.
- 26 Keating FK, Sobel BE, Schneider DJ. Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus. Am J Cardiol 2003; 92: 1362-5.
- 27 Anfossi G, Russo I, Massucco P. et al. Impaired synthesis and action of antiaggregating cyclic nucleotides in platelets from obese subjects: possible role in platelet hyperactivation in obesity. Eur J Clin Invest 2004; 34: 482-9.
- 28 Touyz RM, Schiffrin EL. Blunted inhibition by insulin of agonist-stimulated calcium, pH and aggregatory responses in platelets from hypertensive patients. J Hypertens 1994; 12: 1255-63.