Apoptosis as a Determinant of Atherothrombosis

Alain Tedgui; Ziad Mallat

doi:10.1055/s-0037-1616240

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(01): 420-426
DOI: 10.1055/s-0037-1616240

Research Article

Schattauer GmbH

Apoptosis as a Determinant of Atherothrombosis

Alain Tedgui

¹INSERM U541 and Institut Fédératif de Recherche “Circulation-Paris 7”, Hôpital Lariboisière, Paris, France

,

Ziad Mallat

¹INSERM U541 and Institut Fédératif de Recherche “Circulation-Paris 7”, Hôpital Lariboisière, Paris, France

› Author Affiliations

Abstract

Summary

Clinical manifestations of atherosclerosis are the consequences of atherosclerotic plaque rupture that triggers thrombus formation. Tissue factor (TF) is a key element in the initiation of the coagulation cascade and is crucial in thrombus formation following plaque disruption. TF activity is highly dependent on the presence of phosphatidylserine (PS), an anionic phospholipid that is redistributed on the cell surface during apoptotic death conferring a potent procoagulant activity to the apoptotic cell. Apoptosis occurs in the human atherosclerotic plaque and shed membrane apoptotic microparticles rich in PS are produced in considerable amounts within the lipid core. These microparticles carry almost all TF activity and are responsible for the procoagulant activity of the plaque. Moreover, luminal endothelial cell apoptosis might be responsible for thrombus formation on eroded plaques without rupture. Apoptosis might also play a major role in blood thrombogenicity via circulating procoagulant microparticles that are found at high levels in patients with acute coronary syndromes.

Key words

Atherosclerosis - plaque stability - apoptosis - tissue factor - phosphatidylserine

Full Text

References

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