Thromb Haemost 2001; 86(03): 809-816
DOI: 10.1055/s-0037-1616136
DOI: 10.1055/s-0037-1616136
Review Articles
Combined Effect of Factor V Leiden and Prothrombin 20210A on the Risk of Venous Thromboembolism
Pooled Analysis of 8 Case-control Studies Including 2310 Cases and 3204 ControlsJoseph Emmerich
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,
Frits R. Rosendaal
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,
Marco Cattaneo
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,
Maurizio Margaglione
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,
Valerio De Stefano
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,
Tony Cumming
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,
Valder Arruda
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,
Andreas Hillarp
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,
Jean-Luc Reny
1
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges
Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase,
Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina
(Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum,
Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento
di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy);
San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale
Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San
Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto
di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney,
M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis
Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C.
Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of
Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson
(University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders,
University Hospital, Malmö, Sweden)
,