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Thromb Haemost 2001; 86(03): 809-816
DOI: 10.1055/s-0037-1616136
Review Articles
Schattauer GmbH

Combined Effect of Factor V Leiden and Prothrombin 20210A on the Risk of Venous Thromboembolism

Pooled Analysis of 8 Case-control Studies Including 2310 Cases and 3204 Controls
Joseph Emmerich
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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Frits R. Rosendaal
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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Marco Cattaneo
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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Maurizio Margaglione
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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Valerio De Stefano
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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Tony Cumming
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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Valder Arruda
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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Andreas Hillarp
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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Jean-Luc Reny
1   Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R. M. Bertina (Klinische Epidemiologie en Hematologie C0-P-43, Leids Universitair Medisch Centrum, Leiden, NL); Milano: M. Cattaneo, V. Chantarangkul, L. Tagliabue, P. M. Mannucci (Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy); San Giovanni Rotondo: M. Margaglione, E. Grandone, V. Brancaccio, G. Di Minno (Ospedale Casa Sollievo della Sofferenza, Unità di Ricerca in Aterosclerosi e Thrombosi, San Giovanni Rotondo, Italy); Roma: V. De Stefano, K. Paciaroni, E. Rossi, G. Leone (Istituto di Ematologia, Università Cattolica, Roma, Italy); Manchester: T. Cumming, S. Keeney, M. Bhavnani, C. Hay (University Department of Haematology, Haemostasis and Thrombosis Centre, Manchester Royal Infirmary, Manchester, UK); Campinas: V. R. Arruda, M. C. Ozelo, J. M. Annichino-Bizzachi (Hematology-Hemotherapy Center, State University of Campinas, Campinas-SP, Brasil); Malmö: A. Hillarp, B. Dahlbäck, B. Zöller, P. J. Svensson (University of Lund, Dept. of Clinical Chemistry and Dept. for Coagulation Disorders, University Hospital, Malmö, Sweden)
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the study group for pooled-analysis in venous thromboembolism› Institutsangaben