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Thromb Haemost 2001; 86(03): 777-783
DOI: 10.1055/s-0037-1616131
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Increased Platelet Glycoprotein V Levels in Patients with Coronary and Peripheral Atherosclerosis

The Influence of Aspirin and Cigarette Smoking
A. D. Blann
1   Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
,
F. Lanza
2   INSERM U.311, Etablissement Francais du Sang, Strasbourg, France
,
P. Galajda
1   Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
,
D. Gurney
1   Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
,
S. Moog
2   INSERM U.311, Etablissement Francais du Sang, Strasbourg, France
,
J. P. Cazenave
2   INSERM U.311, Etablissement Francais du Sang, Strasbourg, France
,
G. Y. H. Lip
1   Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
› Author Affiliations
Further Information

Publication History

Received 13 November 2000

Accepted after resubmission 03 April 2001

Publication Date:
14 December 2017 (online)

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Summary

As platelet hyperactivity is important in atherosclerosis and smoking, we hypothesized higher levels of soluble platelet membrane glycoprotein V (gpV) in 95 patients with peripheral artery disease (PAD) and 92 with coronary artery disease (CAD) compared to 99 healthy controls, and examined the effects of aspirin and of smoking two cigarettes on soluble gpV and platelet function. Soluble gpV (ELISA) was significantly raised in, but not between, both PAD and CAD patients, compared to controls (p <0.05). In multivariate analysis, systolic blood pressure, smoking and atherosclerosis (all p <0.01) were significant influences on soluble gpV in the whole study cohort. There was a weak correlation between soluble gpV and another platelet marker, soluble P selectin (p = 0.048). Acute smoking in 14 subjects increased platelet aggregability and beta-thromboglobulin, but not soluble gpV: there were no changes in 11 non-smokers. Five days consumption of aspirin (325 mg daily) by 14 subjects did not influence levels of soluble gpV. Our data indicate that soluble gpV may be a useful new marker of platelet activation in atherosclerosis, but may be influenced by smoking status and blood pressure.

Keywords

Platelets - smoking - atherosclerosis
 

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