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Thromb Haemost 2001; 86(03): 722-726
DOI: 10.1055/s-0037-1616130
Review Articles
Schattauer GmbH

Thrombophilic Risk Factors in Patients with Central Retinal Vein Occlusion

Rossella Marcucci
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Laura Bertini
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Betti Giusti
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Tamara Brunelli
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Sandra Fedi
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Anna Paola Cellai
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Daniela Poli
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Guglielmina Pepe
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Rosanna Abbate
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
,
Domenico Prisco
1   Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy
› Author Affiliations
Further Information

Publication History

Received 18 September 2000

Accepted after resubmission 03 April 2001

Publication Date:
14 December 2017 (online)

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Summary

Few and contrasting data are available on the prevalence of hemostatic risk factors in patients with central retinal vein occlusion (CRVO). Aim of this study was to investigate the metabolic and inherited risk factors for venous thrombosis in 100 CRVO patients (age: 59 yrs; range 18-77) and in 100 controls (age: 56 yrs; range 18-84). In patients homocysteine (Hcy) levels were significantly higher than in controls and were affected by the C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism (p <0.001). The prevalences of activated protein C resistance (APCR), factor V Leiden positivity, elevated PAI-1 and Lp(a) levels were significantly higher in patients with respect to controls. At multivariate analysis, only hyperhomocysteinemia (OR 11, 95% CI 3.6-36.2; p <0.0001) and elevated PAI-1 levels (OR 8.9, 95% CI 3.5-41.3; p <0.01), in addition to hypertension (OR 40.5, 95% CI 8.6-188.8; p <0.00001) and hypercholesterolemia (OR 3.1, 95% CI 1.6-20.5; p <0.05), were independent risk factors for CRVO. These data demonstrate a potential role of hemostatic risk factors in the pathophysiology of CRVO.

Keywords

Central retinal vein occlusion - homocysteine - genetic polymorphisms - fibrinolysis - risk factors
 

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