Regulated Secretion in Endothelial Cells: Biology and Clinical Implications

Yvonne H. Datta; Bruce M. Ewenstein

doi:10.1055/s-0037-1616043

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(05): 1148-1155
DOI: 10.1055/s-0037-1616043

Review Article

Schattauer GmbH

Regulated Secretion in Endothelial Cells: Biology and Clinical Implications

Authors

Yvonne H. Datta

¹Division of Hematology/Oncology, Medical College of Wisconsin, USA
Bruce M. Ewenstein

²Division of Hematology, Brigham & Women’s Hospital, Harvard Medical School, USA

Abstract

Summary

Regulated secretion provides a means by which endothelial cells (EC) can rapidly and selectively alter the microenvironment of individual vascular beds, and modulate the interrelated processes of coagulation, fibrinolysis, and inflammation. The rapid release of high molecular weight multimers of von Willebrand factor (VWF) and surface expression of P-selectin in response to a wide variety of stimuli have been well documented, and are the result of exocytosis of Weibel-Palade bodies (WPB). The regulated release of other EC secretory proteins, including tissue plasminogen activator (tPA), interleukin-8, endothelin-1, and multimerin, has also been described. New light is being shed on how secretory proteins are selectively targeted to storage granules in EC, and on the molecular and cellular events that comprise regulated secretion. Knowledge of the mechanisms of sorting and secretion from EC storage granules may provide basis for new strategies for treating inflammatory and coagulation disorders.

Keywords

Endothelial cells - secretion - Weibel-Palade bodies - coagulation - inflammation

Full Text

References

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