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Thromb Haemost 1999; 82(S 01): 121-123
DOI: 10.1055/s-0037-1615568
Commentaries
Schattauer GmbH

Pharmacokinetics and Pharmacodynamics of Lanoteplase (n-PA)

Thomas K. Nordt
1   From the Abteilung Kardiologie, , Medizinische Klinik und Poliklinik, Universität Freiburg
,
Martin Moser
2   Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Heidelberg, Germany
,
Benedikt Kohler
1   From the Abteilung Kardiologie, , Medizinische Klinik und Poliklinik, Universität Freiburg
,
Wolfgang Kübler
2   Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Heidelberg, Germany
,
Christoph Bode
1   From the Abteilung Kardiologie, , Medizinische Klinik und Poliklinik, Universität Freiburg
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2017 (online)

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Summary

In acute myocardial infarction rapid, complete, and sustained reperfusion of the infarct-related coronary artery is the most important therapeutic principle. Lanoteplase or n-PA, a third-generation plasminogen activator consisting of a deletion and point mutant of tissue-type plasminogen activator (t-PA), is a promising agent to appraoch this therapeutic goal. The molecule exhibits an increased plasma half-life allowing single-bolus administration. In this article, after characterizing the n-PA molecule, the currently available pharmacokinetic and pharmacodynamic data including the results of the InTIME study are reviewed.

Key words

Myocardial infarction - reperfusion - thrombolysis - plasminogen - activator
 

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