A Polymorphism nt 1628G→A (R485K) in Exon 10 of the Coagulation Factor V Gene May Be a Risk Factor for Thrombosis in the Indigenous Thai Population

Thromb Haemost 1998; 80(04): 705-706
DOI: 10.1055/s-0037-1615448

Letters to the Editor

Schattauer GmbH

Motofumi Hiyoshi

¹From the Department of Laboratory Medicine

,

Pasra Arnutti

¹Departments of Pediatrics, Bangkok, Thailand

,

Wichai Prayoonwiwat

²Medicine, Bangkok, Thailand

,

Oytip Nathalang

³Pathology, Pramongkutklao Hospital and College of Medicine, Bangkok, Thailand

,

Chamaiporn Suwanasophon

³Pathology, Pramongkutklao Hospital and College of Medicine, Bangkok, Thailand

,

Rachapat Kokaseam

²Medicine, Bangkok, Thailand

,

Shigemi Hashimoto

¹From the Department of Laboratory Medicine

,

Takayuki Takubo

¹From the Department of Laboratory Medicine

,

Shinichi Tagawa

¹From the Department of Laboratory Medicine

,

Mitsuru Fukui

⁴Laboratory of Statistics, Osaka City University Medical School, Osaka, Japan

,

Noriyuki Tatsumi

¹From the Department of Laboratory Medicine

References
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2 Rees DC. The population genetics of factor V Leiden (Arg506Gln). Br J Haematol 1996; 95: 579-86.
3 Ishida F, Ito T, Ichikawa N, Shimodaira S, Takamiya O, Furihata K, Kiyosawa K, Kitano K. Arg⁵⁰⁶Gln factor V mutation is uncommon in Eastern Asian populations. Blood 1995; 86: 917a.
4 Sifontes MT, Nuss R, Hunger SP, Wilimas J, Jacobson LJ, Manco-Johnson MJ. The factor V Leiden mutation in children with cancer and thrombosis. Br J Haematol 1997; 96: 484-9.
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6 Helley D, Besmond C, Ducrocq R, da Silva F, Guillin M-C, Bezeaud A, Elion J. Polymorphism in exon 10 of the human coagulation factor V gene in a population at risk for sickle cell disease. Hum Genet 1997; 100: 245-8.
7 Dahläck B. Resistance to activated protein C as risk factor for thrombosis: molecular mechanisms, laboratory investigation, and clinical management. Semin Hematol 1997; 34: 217-34.