Download PDF
Thromb Haemost 1999; 82(06): 1779-1780
DOI: 10.1055/s-0037-1614921
Letters to the Editor
Schattauer GmbH

Platelet Multimerin and Its Proteolytic Processing

C. P. M. Hayward
1   From the Departments of Pathology and Molecular Medicine, and Medicine, McMaster University, the Hamilton Health Sciences Corporation, and the Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada
› Author Affiliations
This work was supported by a grant from the Medical Research Council of Canada and by a grant and Research Scholar Award from the Heart and Stroke Foundations of Ontario and Canada.
Further Information

Publication History

Received 31 December 1998

Accepted after resubmission 29 June 1999

Publication Date:
10 December 2017 (online)

Also available at
   Permissions and Reprints

 

 

  • References

  • 1 Polgár J, Magnenat E, Wells TNC, Clemetson KJ. Platelet glycoprotein Ia* is the processed form of multimerin – isolation and determination of N-terminal sequences of stored and released forms. Thromb Haemost 1998; 80: 645-8.
    Thieme ConnectPubMedSearch in Google Scholar
  • 2 Hayward CPM, Hassell J, Denomme G, Rachubinski R, Brown C, Kelton JG. The cDNA sequence of human endothelial cell multimerin: A unique protein with RGDS, coiled-coil, and EGF-like domains, and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X. J Biol Chem 1995; 270: 18246-51.
    CrossrefPubMedSearch in Google Scholar
  • 3 Hayward CPM, Smith JW, Horsewood P, Warkentin TE, Kelton JG. p-155, a multimeric platelet protein that is expressed on activated platelets. J Biol Chem 1991; 266: 7114-20.
    PubMedSearch in Google Scholar
  • 4 Hayward CPM, Warkentin TE, Horsewood P, Kelton JG. Multimerin: A series of large disulfide-linked multimeric proteins within platelets. Blood 1991; 77: 2556-60.
    PubMedSearch in Google Scholar
  • 5 Hayward CPM, Bainton DF, Podor TJ, Smith JW, Stead R, Horsewood P, Warkentin TE, Kelton JG. Multimerin is found in the α-granules of resting platelets and is synthesized by a megakaryocytic cell line. J Clin Invest 1993; 91: 2630-9.
    CrossrefPubMedSearch in Google Scholar
  • 6 Hayward CPM, Cramer EM, Song Z, Zheng S, Fung R, Massé JM, Stead R, Podor TJ. Studies of multimerin in human endothelial cells. Blood 1998; 91: 1304-17.
    PubMedSearch in Google Scholar
  • 7 Hayward CPM, Song Z, Zheng S, Fung R, Pai M, Massé JM, Cramer EM. Multimerin processing by cells with and without pathways for regulated protein secretion. Blood 1999; 94: 1337-47.
    PubMedSearch in Google Scholar
  • 8 Hayward CPM. Multimerin: A bench to bedside chronology of a unique platelet and endothelial cell protein – from discovery to function to abnormalities in disease. Clin Invest Med 1997; 20: 176-87.
    PubMedSearch in Google Scholar