The Factor V Leiden Mutation and the Prothrombin G20210A Mutation Was not Found in Japanese Patients with Pulmonary Thromboembolism

Thromb Haemost 1999; 82(06): 1769
DOI: 10.1055/s-0037-1614913

Letters to the Editor

Schattauer GmbH

Authors

A. Ro

¹From Tokyo Medical Examiner’s Office, Japan
M. Hara

²Department of Forensic Medicine, Saitama Medical School, Japan
A. Takada

¹From Tokyo Medical Examiner’s Office, Japan

²Department of Forensic Medicine, Saitama Medical School, Japan

References
1 Giuntini C, Ricco GD, Marini C, Melillo E, Palla A. Pulmonary embolism: epidemiology. Chest 1995; 107 Suppl: 3s-9s.
2 Kumasaka N, Sakuma M, Shirato K. Incidence of pulmonary thromboembolism in Japan. Jpn Circ J 1999; 63: 439-41.
3 Ripoll L, Paulin D, Thomas S, Drouet O. Multiple PCR-mediated site-directed mutagenesis for one-step determination of Factor V Leiden and G20210A transition of the prothrombin gene. Thromb Haemost 1997; 78: 960-1.
4 Bertina RM, Koeleman BCP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
5 Proot SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1995; 88: 3698-703.