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Thromb Haemost 1999; 82(05): 1516-1521
DOI: 10.1055/s-0037-1614864
Rapid Communications
Schattauer GmbH

The Effects of Angiotensin Metabolites on the Regulation of Coagulation and Fibrinolysis in Cultured Rat Aortic Endothelial Cells

Hiromi Nishimura
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Hajime Tsuji
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Haruchika Masuda
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Teruhisa Kasahara
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Masami Yoshizumi
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Tatsuya Sugano
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Shinzo Kimura
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Hidehiko Kawano
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Yasufumi Kunieda
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Shingo Yano
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Katsumi Nakagawa
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Hidetsugu Kitamura
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Yoshifumi Nakahara
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Shohei Sawada
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Masao Nakagawa
1   From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
› Author Affiliations
Further Information

Publication History

Received 05 April 1999

Accepted after revision 07 July 1999

Publication Date:
09 December 2017 (online)

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Summary

Not only angiotensin II (Ang II) but also other angiotensin metabolites such as angiotensin I (Ang I), angiotensin III (Ang III), angiotensin IV, or angiotensin 1-7 have recently been reported to have various activities. Few data, however, are available on the regulation of thrombus formation. In this study, we investigated the effects of angiotensin metabolites on the mRNA expression of tissue factor (TF), tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor-1 (PAI-1), and tissue type plasminogen activator (TPA) in cultured rat aortic endothelial cells. None of the used angiotensin metabolites altered TFPI or TPA mRNA expression levels. Ang I, Ang II, and Ang III made TF and PAI-1 mRNA inductions which were inhibited by an selective antagonist of angiotensin II type 1 receptors. These metabolites made TF predominant to TFPI or PAI-1 to TPA, and could render endothelial cells thrombogenic.

Key words

Angiotensin - thrombosis - fibrinolysis - tissue factor - plasminogen activator inhibitor 1
 

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