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Thromb Haemost 1999; 82(01): 51-57
DOI: 10.1055/s-0037-1614629
Rapid Communication
Schattauer GmbH

Antithrombogenic Coating of Stents Using a Biodegradable Drug Delivery Technology

R. Herrmann
2   From the I. Medizinische Klinik, Technische Universität München, Munich, Germany
,
G. Schmidmaier
1   Inst. Exp. Onkologie und Therapieforschung, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
,
B. Märkl
2   From the I. Medizinische Klinik, Technische Universität München, Munich, Germany
,
A. Resch
2   From the I. Medizinische Klinik, Technische Universität München, Munich, Germany
,
I. Hähnel
2   From the I. Medizinische Klinik, Technische Universität München, Munich, Germany
,
A. Stemberger
1   Inst. Exp. Onkologie und Therapieforschung, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
,
E. Alt
2   From the I. Medizinische Klinik, Technische Universität München, Munich, Germany
› Author Affiliations
Further Information

Publication History

Received 14 August 1998

Accepted after resubmission 03 March 1999

Publication Date:
11 December 2017 (online)

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Summary

To reduce the thrombogenic properties of coronary artery stents, a biodegradable polylactic acid (PLA) stent coating with an incorporated thrombin inhibitor and a platelet aggregation inhibitor has been developed. In an ex vivo human stasis model, its effect on platelets, plasmatic coagulation and its release characteristics were studied using whole blood. Bare steel and bare gold-surface stents were compared to steel and gold-surface stents coated with PLA (30 kDa) containing 5% polyethyleneglycol (PEG)-hirudin and 1% iloprost, with an empty tube as control. Markers of activated coagulation (prothrombin fragment F1-2 and thrombin-antithrombin III complex, TAT), were assayed and the release of drugs from the coating was assessed by aPTT and collagen-induced platelet aggregation. Bare steel and gold stents were completely covered by a blood clot, and high levels of coagulation markers (F1-2 fragment and TAT) were detected. No differences in the thrombogenic properties were found between bare gold or steel stents. Coated stents were free of blood clots and only minor elevations of markers were detected. Release data from in-vitro studies over 90 days showed a gradual release of the drugs with an initial exponential release characteristic for PEG-hirudin, slow release of iloprost and a 10% degradation of the PLA carrier. This drug releasing biodegradable coating effectively reduced thrombus formation independent of the metallic surface.

 

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