Thromb Haemost 1999; 81(05): 711-714
DOI: 10.1055/s-0037-1614559
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Clotting Activation after Transjugular Intrahepatic Portosystemic Stent Shunt

Stefania Basili
2   Dipartimento di Terapia Medica
,
Merli Manuela
3   Cattedra di Gastroenterologia, Università »La Sapienza«, Rome, Italy
,
Domenico Ferro
1   From the Istituto I Clinica Medica
,
Raffaella Lionetti
3   Cattedra di Gastroenterologia, Università »La Sapienza«, Rome, Italy
,
Elisabetta Rossi
1   From the Istituto I Clinica Medica
,
Oliviero Riggio
3   Cattedra di Gastroenterologia, Università »La Sapienza«, Rome, Italy
,
Valentina Valeriano
3   Cattedra di Gastroenterologia, Università »La Sapienza«, Rome, Italy
,
Livio Capocaccia
3   Cattedra di Gastroenterologia, Università »La Sapienza«, Rome, Italy
,
Francesco Violi
1   From the Istituto I Clinica Medica
› Author Affiliations
Further Information

Publication History

Received 15 December 1998

Accepted after revision 25 January 1999

Publication Date:
09 December 2017 (online)

Summary

Background and Aim. Aim of the study was to investigate the behaviour of clotting system in peripheral circulation of cirrhotic patients undergoing transjugular intrahepatic portosystemic stent shunt (TIPS). Methods. Clotting variables and endotoxemia were measured 48 h and 30 days after TIPS in patients randomised to receive heparin or not. Results. Forty-eight hours after TIPS, a significant increase of prothrombin fragment F1+2 was observed; such increase was less evident in patients given heparin. Similar findings were observed for endotoxemia, which, however, was not affected by heparin treatment. Thirty days after TIPS procedure prothrombin fragment F1+2 and endotoxemia returned to baseline values independently of the treatment given. Conclusion. This study shows that TIPS is associated with an increase of clotting activation which might contribute to acute thrombosis observed after this procedure.

 
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