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Thromb Haemost 2000; 83(01): 65-69
DOI: 10.1055/s-0037-1613759
Commentary
Schattauer GmbH

The Half-life of Infused Factor VIII Is Shorter in Hemophiliac Patients with Blood Group 0 than in those with Blood Group A

André J. Vlot
1   From The van Creveldkliniek, University Medical Center Utrecht, Utrecht
2   From The Department of Haematology, Graduate School of Biomembranes, University Medical Center Utrecht, Utrecht
,
Evelien P. Mauser-Bunschoten
1   From The van Creveldkliniek, University Medical Center Utrecht, Utrecht
,
Antoanette G. Zarkova
3   The National Center of Haematology and Transfusiology, Sofia, Bulgaria, The Netherlands
,
Els Haan
1   From The van Creveldkliniek, University Medical Center Utrecht, Utrecht
,
Cas L. J. J. Kruitwagen
4   The Center for Biostatistics, University of Utrecht, The Netherlands
,
Jan J. Sixma
2   From The Department of Haematology, Graduate School of Biomembranes, University Medical Center Utrecht, Utrecht
,
H. Marijke van den Berg
1   From The van Creveldkliniek, University Medical Center Utrecht, Utrecht
› Author AffiliationsThis work was supported in part by the Van Creveld Foundation.
Further Information

Publication History

Received 08 June 1999

Accepted after revision 08 September 1999

Publication Date:
06 December 2017 (online)

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Summary

A considerable inter-individual variation in half-life of infused factor VIII is observed among patients with hemophilia A. The factors contributing to this wide range in factor VIII half-life are not known in detail. We analysed the pharmacokinetics of infused factor VIII in 32 patients with hemophilia A, comprising 20 brothers from 10 families, 3 and 4 brothers from 2 families, and 5 patients from 5 single families, respectively. Multiple linear regression analysis was used to asses the effect of several variables on factor VIII half-life. We found that the pre-infusion von Willebrand factor antigen levels (vWF:Ag) were positively correlated with factor VIII half-life (r = 0.52, p = 0.002), i. e., each variable was associated with about 27% of the variance of the other. In fraternal pairs, familial clustering was significant for AB0 blood group (p < 0.001), but could not be detected for factor VIII half-lives or pre-infusion vWF:Ag levels. vWF:Ag level (p = 0.001) and AB0 blood group (p = 0.003) significantly determined factor VIII half-life, whereas age, length, bodyweight, the presence or absence of a factor VIII gene inversion, and Rhesus phenotype did not. Patients with blood group 0 exhibited a statistically significant shorter factor VIII half-life than patients with blood group A (15.3 versus 19.7 h, respectively) (p = 0.003). Patients with blood group A and 0 differ in respect to the presence of anti-A antibodies in the latter. It is possible that these anti-A antibodies interact with endogenous vWF, thus affecting the half-life time of the factor VIII/vWF complex.

Key words

Hemophilia - factor VIII - von Willebrand factor - half-life - AB0 blood group system
 

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