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Thromb Haemost 2000; 83(01): 1-2
DOI: 10.1055/s-0037-1613745
Commentary
Schattauer GmbH

High Levels of Factor VIII and Venous Thrombosis

F. R. Rosendaal
1   From the Departments of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
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Publication History

Publication Date:
06 December 2017 (online)

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  • References

  • 1 Schnitzler J. Über konstitutionelle und konditionelle Mitbedingtheit postoperativer Vorkommnisse. Wien Klin W Schr 1926; I: 26.
    PubMedGoogle Scholar
  • 2 Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Haemorrh 1965; 13: 516-30.
    PubMedGoogle Scholar
  • 3 Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981; 68: 1370-3.
    CrossrefPubMedGoogle Scholar
  • 4 Schwarz HP, Fischer M, Hopmeier P, Batard MA, Griffin JH. Plasma protein S deficiency in familial thrombotic disease. Blood 1984; 64: 1297-1300.
    PubMedGoogle Scholar
  • 5 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognised mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-8.
    CrossrefPubMedGoogle Scholar
  • 6 Bertina RM, Koeleman RPC, Koster T, Rosendaal FR, Dirven RJ, De Ronde H, Van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
    CrossrefPubMedGoogle Scholar
  • 7 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
    PubMedGoogle Scholar
  • 8 Koster T, Blann AD, Briët E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 1995; 345: 152-5.
    CrossrefPubMedGoogle Scholar
  • 9 Rosendaal FR. Risk factors for venous thrombotic disease. Thromb Haemost 1999; 82: 610-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Tait RC, Walker ID, Reitsma PH, Islam SI, McCall F, Poort SR, Conkie JA, Bertina RM. Prevalence of protein C deficiency in the healthy population. Thromb Haemost 1995; 73: 87-93.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Tait RC, Walker ID, Perry DJ, Islam SI, Daly ME, McCall F, Conkie JA, Carrell RW. Prevalence of antithrombin deficiency in the healthy population. Br J Haematol 1994; 87: 106-12.
    CrossrefPubMedGoogle Scholar
  • 12 Jick H, Slone D, Westerholm B, Inman WHW, Vessey MP, Shapiro S, Lewis GP, Worcester J. Venous thromboembolic disease and ABO blood type. Lancet 1969; i: 539-42.
    PubMedGoogle Scholar
  • 13 Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR. The effect of ABO blood groups on the diagnosis of von Willebrand disease. Blood 1987; 69: 1691-5.
    PubMedGoogle Scholar
  • 14 Weis HJ, Sussman I, Hoyer LW. Stabilization of factor VIII in plasma by the von Willebrand factor. J Clin Invest 1997; 60: 390-404.
    PubMedGoogle Scholar
  • 15 Kamphuisen PW, Houwing-Duistermaat JJ, van Houwelingen JC, Eikenboom JCJ, Bertina RM, Rosendaal FR. Familial clustering of factor VIII and von Willebrand factor levels. Thromb Haemost 1998; 79: 323-7.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Kamphuisen PW, Lensen RPM, Houwing-Duistermaat JJ, Eikenboom JCJ, Harvey M, Bertina RM, Rosendaal FR. Heritability of elevated factor VIII antigen levels in families with thrombophilia. Thromb Haemost 1999; 82 (abstract): 418-9.
    PubMedGoogle Scholar
  • 17 Mansvelt EPG, Laffan M, McVey JH, Tuddenham EGD. Analysis of the F8 gene in individuals with high plasma factor VIII:C levels and associated venous thrombosis. Thromb Haemost 1998; 80: 561-5.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 18 Kraaijenhagen RA, ‘t Anker ES, Koopman MMW, Reitsma PH, Prins MH, van den Ende A, Büller HR. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism. Thromb Haemost 1999; 83: 5-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 O’Donnell J, Mumford AD, Manning RA, Laffan M. Elevation of FVIII in venous thromboembolism is persistent and independent of the acute phase response. Thromb Haemost 1999; 83: 10-3.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 20 O’Donnell J, Tuddenham EGD, Manning R, Kemball-Cook G, Johnson D, Laffan M. High prevalence of elevated FVIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction. Thromb Haemost 1997; 77: 825-8.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 21 Kamphuisen PW, Eikenboom JCJ, Vos HL, Pablo R, Sturk A, Bertina RM, Rosendaal FR. Increased levels of factor VIII and fibrinogen in patients with venous thrombosis are not caused by acute phase reactions. Thromb Haemost 1999; 81: 680-3.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 22 Vandenbroucke JP, Koster T, Briët E, Reitsma PH, Bertina RM, Rosendaal FR. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994; 344: 1453-7.
    CrossrefPubMedGoogle Scholar
  • 23 Bloemenkamp KWM, Helmerhorst FM, Rosendaal FR, Vandenbroucke JP. Venous thrombosis, oral contraceptives and high factor VIII levels. Thromb Haemost 1999; 82: 1024-7.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 24 Eichinger S, Minar E, Hirschl M, Bialonzcyk C, Stain M, Schneider B, Speiser W, Lechner K, Kyrle PA. The risk of early recurrent venous thromboembolism (VTE) in patients with increased factor VIII:C (FVIII) and a first episode of spontaneous VTE. Thromb Haemost 1999; 82 (abstract): 5-6.
    PubMedGoogle Scholar