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Thromb Haemost 2002; 87(01): 32-36
DOI: 10.1055/s-0037-1612939
Review Article
Schattauer GmbH

FV HR2 Haplotype as Additional Inherited Risk Factor for Deep Vein Thrombosis in Individuals with a High-Risk Profile

Maurizio Margaglione
1   Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo
,
Anna Bossone
1   Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo
,
Donatella Coalizzo
1   Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo
,
Giovanna D’Andrea
1   Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo
,
Vincenzo Brancaccio
2   Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli
,
Antonio Ciampa
3   Divisione di Ematologia, Ospedale “G. Moscati”, Avellino
,
Elvira Grandone
1   Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo
,
Giovanni Di Minno
4   Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy
› Author Affiliations
Further Information

Publication History

Received 13 February 2001

Accepted after resubmission 24 September 2001

Publication Date:
14 December 2017 (online)

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Summary

A number of strongly linked polymorphisms within the Factor V gene (FV HR2 haplotype) has been identified as a cause of resistance to activated protein C, and has suggested a modest risk factor for vein thrombosis. We investigated the frequency of the HR2 haplotype in 433 consecutive patients with confirmed deep vein thrombosis and 326 controls. The HR2 haplotype was more frequent in patients (15.2%) than in controls (10.1%). The risk of thrombosis among carriers of this haplotype was significantly increased (odds ratio: 1.6 [95% CI: 1.0-2.5]). The estimated risk associated with the HR2 haplotype was 1.8 (95% CI: 1.1-2.9) in subjects with (n = 255), and 1.4 (95% CI: 0.8-2.4) in those without (n = 178) acquired risk factors for vein thrombosis. After adjustment for sex, FV Leiden and FII A20210 mutations, the estimated risk of vein thrombosis among carriers of the HR2 haplotype was 1.8 (95% CI: 1.1-2.8). Present data indicate that the HR2 haplotype is independently associated with vein thrombosis among individuals with a highrisk profile.

Keywords

HR2 haplotype - FV gene - inherited risk factors - vein thrombosis
 

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