Shorea bracteolate is a big forest tree and locally known as 'Meranti paang'. These Shorea species are known to contain different natural compounds such as terpenoids, flavonoids,
coumarins, and resveratrol oligomers. The existing data showed that the most isolated
compounds are resveratrol oligomers. The chemistry of known organic compounds such
as terpenoids, coumarin and resveratrol oligomers is interrelated with biological
activities. However, the knowledge of the other isolated compounds is very limited.
Resveratrol oligomers isolated from the genus Shorea and its extracts show good biological activities including brine shrimps lethality
bioassay, anti HIV-activity [1], antibacterial activity, 5α-reductase inhibitor activity
[2], antihepatotoxic activity, and cytotoxicity [3]. The air-dried stem bark of S.
bracteolate was extracted with 6L of acetone and concentrated at 60oC with rotary evaporator to afford 47.7 g of free tannin crude extract. The crude
extract was fractionated using vacuum liquid chromatography (VLC). Isolation and purification
of compounds used several chromatographic methods including radial, column and preparative
thin layer chromatografies to obtaine three known resveratrol oligomers namely laevifonol
(1), hemsleyanol D (2) and diptoindonesin F (3). The structure of the isolated compound
was determined based on analysis of spectroscopic data, including NMR, UV, IR and
comparison with previous reported data.
Fig. 1
Universiti Teknologi MARA is acknowledged for financial and technical supports.
[1] Dai, J.R, Hallock, Y.F, Cardellina II, J.H.; Boyd, M.R. J. Nat. Prod, 1998, 61,
351 – 353
[2] Hirano, Y, Kondo, R, and Sakai, K. J. Wood Sci, 2001, 47, 308 – 312.
[3] Patcharamun, W, Sichaem, J, Siripong, P, Khumkratok, S, Jong-aramruang, J, Tip-pynag,
S, 2011, 82, 489 – 492
