Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608145
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Bioactive chemical constituents isolated from the root of Neolitsea acuminatissima

HH Ko
1   Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan
2   Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan
,
CC Chang
1   Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan
,
CH Lin
2   Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan
3   School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
,
YH Kuo
4   Department of Chinese Pharmaceutical Science and Chinese Medicine Resources, China Medical University, Taichung, Taiwan
5   Department of Biotechnology, Asia University, Taichung, Taiwan
,
IS Chen
3   School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
,
HS Chang
2   Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan
3   School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 
 

    Neolitsea acuminatisima (Hayata) Kanehira & Sasaki is genus of Neolistea (Lauraceae), an endemic species in Taiwan. In fact, the chemical constituents of the root of this plant have seldom been investigated previously. It is worth to verify the phytochemistry and secondary metabolites of the root of N. acuminatissima. One new carboline alkaloid, demethoxydaibucarboline A (1) and three new eudesmanolide type sesquiterpenes, methylneolitacumone A (2), neolitacumone E (3), and dineolitacumone C (4), along with twelve known compounds neolitacumones A-C (5 – 7), b-sitosterol (8), quercetin (9), dihydroquercetin (10), epicatechin (11), oplopanone (12), zeorin (13), linderaggrine A (14), clovane-2β,9α-diol (15), and stigmast-5-ene-3b-yl formate (16) were isolated from the dichloromethane and ethyl acetate-soluble layers of the root of N. acuminatissima. All compounds were obtained by column chromatography and their structures were spectroscopically determined by 1D, 2D NMR and MS. In this present study, the bioactivity of the isolates was also reported.


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