Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608138
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Seco-cassine diterpenoids and cytotoxic activities of the constituents from the roots of Acacia farnesiana

YC Chen
1   School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
HH Liu
2   Department of Chinese Pharmaceutical Science and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
HZ Lee
3   School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)


    Acacia farnesiana (L.) Willd (Leguminosae) is an erect pantropic shrub with forking prickles and widely distributed in the southern part of Taiwan [1]. The preliminary study showed the methanolic extract of its root owning selected cytotoxicity against the HSC-3 cancer cell line. The MeOH extract was partitioned into n-hexane, EtOAc, n-BuOH and H2O-soluble layers. Investigation of the active n-hexane- and EtOAc-soluble fractions of A. farnesiana led to the isolation of six new diterpenoids, farnesiranes CI, CII, DI, DII, EI, and EII, together with 18 known compounds. Among these compounds, farnesirane CI in 30µM showed the cytotoxic activity against HSC-3 cell line. The structures of these compounds were determined through spectral data.

    [1] Huang TC, Ohashi H. Leguminosae in Flora of Taiwan, 2nd edition, Vol. 2. Taipei: Editorial Committee of the Flora of Taiwan; 1993: 162 – 396