It has been brought to the publisher's attention that the reference citations in [Table 1] were incorrect in the above article in Seminars in Thrombosis and Hemostasis, Volume 43, Number 6, 2017 (DOI: 10.1055/s-0037-1603361).
The references cited in the table are provided below. The correct table appears on the next page.
5 Breuer L, Ringwald J, Schwab S, Köhrmann M. Ischemic stroke in an obese patient receiving dabigatran [letter]. N Engl JMed 2013;368(25):2440–2442
6 Douros A, Schlemm L, Bolbrinker J, Ebinger M, Kreutz R. Insufficient anticoagulation with dabigatran in a patient with short bowel syndrome [letter]. Thromb Haemost 2014;112(02):419–420
7 Sargento-Freitas J, Silva F, Pego J, Duque C, Cordeiro G, Cunha L. Cardioembolic stroke in a patient taking dabigatran etexilate: the first case report of clinical and pharmacologic resistance [letter]. J Neurol Sci 2014;346(1–2):348–349
8 Lee D, DeFilipp Z, Judson K, Kennedy M. Subtherapeutic anticoagulation with dabigatran following Roux-en-Y bypass surgery [letter]. J Cardiol Cases 2013;8:e49–e50
Table 1
Published reports for dabigatran and below expected within therapy (or unexpectedly low) plasma concentrations
Patient number
|
Sex/Age
|
Dose (mg)
|
Duration of dabigatran use
|
Time to concentration measurement
|
Indication
|
Concomitant drugs
|
Thrombotic, ischemic or embolic events
|
Dabigatran concentration method
|
Dabigatran concentration
|
aPTT
|
Comments and other potential contributors
|
1.
Breuer et al, 20135
|
M/48
|
150 mg bd
|
∼31 d
|
28 and 31 d
|
AF paroxysmal
|
Omeprazole
|
Cerebral infarction, embolic
|
Hemoclot
|
Trough not detectable day of stroke, 10 h post dose
After witnessed intake for 3 d, peak 50 ng/mL at 4 h
|
Not reported
|
Weight 153 kg. BMI 44.7, creatinine clearance 163 mL/min.
|
2.
Douros et al, 20146
|
F/81
|
110 mg bd
|
Not stated
|
3 mo
|
AF
|
Pantoprazole
Lercanidipine
Clonidine
Metoprolol
Triamterene
Hydrochlorothiazide
Furosemide
Isosorbide mononitrate
|
Dysarthria, facial palsy with AF, presumed diagnosis of cardioembolic stroke of cerebral artery
|
Hemoclot
|
Peak and trough concentrations, 2 and 12 h after witnessed administration, 31 and 21 ng/mL
|
Normal at dabigatran trough
|
Short-gut syndrome following surgery for embolic mesenteric ischemia
SNPs affecting liver carboxylesterase and P-glycoprotein
GFR (37–43 mL/min).
|
3.
Sargento-Freitas et al, 20147
|
F/70
|
110 mg bd
|
31 d
|
31 d
|
AF, acute ischemic stroke, occlusion terminal segment right internal carotid artery
|
Lorazepam
Mirtazapine
Furosemide
Fluoxetine
Simvastatin
Bisoprolol
Ramipril
Digoxin
Omeprazole
|
None
|
Hemoclot
|
Peak concentrations after confirmed intake (ng/mL): 1) 40.6 at 31 d, 110 mg bd
2) 41.9 at 5 d, 150 mg bd
3) 45.0 at 7 d, 150 mg bd, interacting medicines stopped.
|
Normal 7 h after dose in hospital, and at each point when dabigatran concentrations measured.
|
Creatinine clearance 65 mL/min
|
4.
Lee et al, 20138
|
F/67
|
Dose not stated
|
9 mo
|
9 mo
|
AF
|
Pantoprazole
|
None
|
Not stated
|
Trough concentration 21 ng/mL
|
Not measured
|
Roux-en-Y gastric bypass.
|
Abbreviations: aPTT, activated partial thromboplastin time; AF, atrial fibrillation; bd, twice a day; BMI, body mass index; GFR, glomerular filtration rate; SNP, single nucleotide polymorphism.
#
No conflict of interest has been declared by the author(s).
Address for correspondence
Ruth L. Savage, MBBS, MSc (Clin Pharmacol)
Centre for Adverse Reactions Monitoring (CARM), New Zealand Pharmacovigilance Centre
Department Preventive and Social Medicine, University of Otago
PO Box 913, Dunedin
New Zealand