Gesundheitswesen 2017; 79(08/09): 656-804
DOI: 10.1055/s-0037-1605848
Vorträge
Georg Thieme Verlag KG Stuttgart · New York

Association between saturated fat and low-grade inflammation modified by accelerometer-measured physical activity in adolescents

C Harris
1   Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg
,
S Koletzko
2   Ludwig-Maximilians-Universität, Dr. von Hauner Children's Hospital, München
,
T Schikowski
3   IUF – Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf
,
A von Berg
4   Marien-Hospital Wesel, Department of Pediatrics, Wesel
,
H Schulz
1   Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg
5   Pneumology Center Munich (CPC-M), German Center for Lung Research, München
,
M Standl
1   Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg
› Author Affiliations
Further Information

Publication History

Publication Date:
01 September 2017 (online)

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    Introduction:

    Low-grade inflammation in adolescence can be indicative of future cardiovascular disease risk. Understanding the integrated role of relevant lifestyle factors, such as dietary saturated fat (SFA) and physical activity (PA), is important for effective primary prevention. This study evaluated the association of dietary SFA with high-sensitivity C-reactive protein (hs-CRP), a marker of low-grade inflammation, in 15-year-olds. Further, interactions between dietary SFA and different levels of PA were assessed.

    Methods:

    Children from the GINIplus and LISAplus birth cohorts with complete data on SFA, PA and hs-CRP at age 15 years were included (N = 793). SFA intake (% of total kcal) was estimated from food frequency questionnaires. PA (average min/day) was measured with accelerometers, and classified into moderate-to-vigorous (MVPA) or lifestyle (LSPA). Hs-CRP was analysed in serum and categorized into 3 levels (I, II, III). Sex-stratified associations between SFA and hs-CRP were assessed by multinomial logistic regression. Interaction terms were included between SFA and PA levels (MVPA and LSPA). In the event of significant interactions, analyses were performed stratified by tertiles of the relevant PA level.

    Results:

    An inverse association was observed between SFA and hs-CRP in males (hs-CRP II vs. I: OR = 0.85 [95% CI = 0.76; 0.96]). A significant interaction was present for LSPA but not MVPA in both sexes. Stratified analyses indicated a significant inverse association between SFA and hs-CRP for males in the highest LSPA tertile (hs-CRP II vs. I: OR = 0.67 [95%CI = 0.517; 0.858]; hs-CRP III vs. I: OR = 0.72 [95%CI = 0.55; 0.943]).

    Conclusion:

    Higher dietary SFA might be favorable in a sex-specific manner, although this should be interpreted in the context of other correlated nutrients. Males who spent the most time active presented benefits, highlighting the potential of considering the synergistic effects of diet and lifestyle PA in disease prevention.


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