Abstract
Polycystic ovary syndrome (PCOS) is a complex disorder which interacts with other
genetic and environmental factors to cause dysregulation of steroidogenesis and anovulation
as well as insulin resistance. Treatments which address the long-term effects of this
unique combination of reproductive and metabolic dysfunction are needed. Over the
past decade, new insights into the genetic factors of PCOS and biotechnological advances
have led to potential treatments for women with PCOS. These treatments include both
new potent pharmaceutical compounds and repurposed drugs which target different steps
in metabolic-reproductive pathways to improve long-term health of women with PCOS.
These new therapies target key enzymes involved in steroidogenesis, regulatory pathways
of gonadotropin secretion, or lower oxidative stress. We review in this article the
current common treatments of PCOS, recent developments in the field, and current information
on the mode of action, efficacy, and safety of emerging therapeutic compounds.
Keywords
polycystic ovary syndrome - genetics - new treatments
