Aktuelle Ernährungsmedizin 2017; 42(03): 241-272
DOI: 10.1055/s-0037-1603277
Poster
Georg Thieme Verlag KG Stuttgart · New York

NUTRITIONAL ASSESSMENT IN PATIENTS AFFECTED BY MITOCHONDRIAL CYTOPATHIES (NAMITO STUDY)

Authors

  • E Aubry

    1   Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Bern University Hospital and University of Bern, Bern

  • C Aeberhard

    1   Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Bern University Hospital and University of Bern, Bern

  • L Bally

    1   Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Bern University Hospital and University of Bern, Bern

  • S Mühlebach

    2   Department of Clinical Pharmacy and Epidemiology, University of Basel, Basel, Switzerland

  • Z Stanga

    1   Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Bern University Hospital and University of Bern, Bern
Further Information

Publication History

Publication Date:
20 June 2017 (online)

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Introduction:

Patients suffering mitochondrial cytopathy are at high risk for malnutrition. Malnutrition worsen the course of patients with mitochondrial cytopathy. This population suffer often from gastrointestinal symptoms (e.g. dysphagia, intestinal dysmotility, gastroparesis), which considerably influences nutritional intake and therefore deteriorate nutritional state [1 The literature in this regard is very sparse.]

Objectives:

The aim of the study was to assess the nutritional risk, to investigate the nutritional status and the quality of life (QoL) of this population [2].

Methods:

Prospective observational cohort study comparing outpatients with mitochondrial cytopathies to healthy controls. Nutritional screening (NRS-2002) and a full nutritional assessment were conducted, including quantitative and qualitative analysis of dietary habits (7-days food recall protocol), body composition measurements (Bioimpedance analysis and anthropometrics) and rest energy expenditure (indirect calorimetry). A QoL questionnaire (SF36v2) was completed as well. The data were completed with blood sampling and 24-hours urine analysis. The study was registered with the Ethics Committee number KEK-BE 242/2014 and on ClinicalTrials.gov with the number NCT02375438.

Results:

Twenty-six patients were included: 11 in the patients' group (7 men and 4 women) and 15 in the control group (8 men and 7 women). The nutritional screening showed no high risk of malnutrition in both groups. The nutritional assessment showed, that patients had an inadequate energy intake and a significant lower protein intake compare to healthy control. Significant differences were found in every single category of the QoL questionnaire comparing both groups. The physical components score presented the highest difference.

Conclusion:

No patient showed a high risk of malnutrition. It was shown that despite the intake of dietary supplements in almost all patients there was a rational to increase protein portion and to adapt the energy supply to improve disease-related symptoms and QoL. Further studies should investigate the possibly positive influence of ketogenic and isocaloric high fat diet and dietary supplements on the course of the disease.

References:

[1] El-Hattab AW, Scaglia F, Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations and therapeutic options. Neurotherapeutics 2013;10(2):186 – 98.

[2] Jeejeebhoy KN, Nutritional Assessment. Nutrition 2000;16(7 – 8):585 – 90.

Disclosure of Interest:

None declared.


No conflict of interest has been declared by the author(s).