Diabetologie und Stoffwechsel 2017; 12(S 01): S1-S84
DOI: 10.1055/s-0037-1601630
Vorträge
Stress und psychische Erkrankungen
Georg Thieme Verlag KG Stuttgart · New York

Associations between pro- and anti-inflammatory cytokines and depressive symptoms in patients with diabetes – potential differences by diabetes type and depression screening instruments

F Budden
1   Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
,
A Schmitt
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
,
C Herder
1   Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
,
A Reimer
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
,
B Kulzer
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
4   Department for Psychology, Otto Friedrich University of Bamberg, Bamberg, Germany
,
M Roden
1   Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
5   Department for Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
,
T Haak
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
4   Department for Psychology, Otto Friedrich University of Bamberg, Bamberg, Germany
,
N Hermanns
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
4   Department for Psychology, Otto Friedrich University of Bamberg, Bamberg, Germany
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Publikationsverlauf

Publikationsdatum:
05. Mai 2017 (online)

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    Background:

    Subclinical inflammation has been implicated in the development of depression, a common comorbidity of type 1 diabetes (T1D) and type 2 diabetes (T2D). This study aimed to compare the relationships of immune mediators with depressive symptoms between patients with T1D and T2D.

    Materials and methods:

    Six biomarkers of inflammation were measured in serum samples of participants with elevated depressive symptoms and T1D (n = 389, diabetes duration 15 ± 11 years) or T2D (n = 204, diabetes duration 13 ± 8 years). Subclinical depression was examined using three questionnaires (Center for Epidemiologic Studies Depression [CES-D] score, Patient Health Questionnaire [PHQ9], 5-item World Health Organization Well-Being Index [WHO5]).

    Results:

    In T1D, levels of interleukin-1 receptor antagonist (IL-1RA) were positively associated with depression for two scores (CES-D, PHQ9), high-sensitivity C-reactive protein (hsCRP) was positively associated with depression for one score (WHO5) after adjustment for age, sex, study, BMI, diabetes duration, metabolic variables, medication and comorbidities (p = 0.008 – 0.042). In T2D, IL-18 and IL-1RA were positively associated with depression for two scores (IL-18: PHQ9, WHO5; IL-1RA: CES-D, WHO5), hsCRP for one score (PHQ9), and adiponectin showed an inverse association with depression for one score (PHQ9) after adjustment (p = 0.006 – 0.048). No associations were found for IL-6 and monocyte chemoattractant protein-1 (MCP-1/CCL2).

    Conclusions:

    Associations between biomarkers of inflammation and depressive symptoms in patients with diabetes were most consistent for IL-1RA and hsCRP. In T2D, there was additional evidence for associations between IL-18 and (inversely) adiponectin with depressive symptoms. The strength of the associations depended on diabetes type and the method used to assess depressive symptoms.


     

    Die Autoren geben an, dass kein Interessenkonflikt besteht.