Diabetologie und Stoffwechsel 2017; 12(S 01): S1-S84
DOI: 10.1055/s-0037-1601630
Vorträge
Stress und psychische Erkrankungen
Georg Thieme Verlag KG Stuttgart · New York

Associations between pro- and anti-inflammatory cytokines and depressive symptoms in patients with diabetes – potential differences by diabetes type and depression screening instruments

F Budden
1   Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
,
A Schmitt
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
,
C Herder
1   Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
,
A Reimer
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
,
B Kulzer
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
4   Department for Psychology, Otto Friedrich University of Bamberg, Bamberg, Germany
,
M Roden
1   Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
5   Department for Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
,
T Haak
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
4   Department for Psychology, Otto Friedrich University of Bamberg, Bamberg, Germany
,
N Hermanns
2   German Center for Diabetes Research (DZD), München-Neuherberg, Germany
3   Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad Mergentheim, Germany
4   Department for Psychology, Otto Friedrich University of Bamberg, Bamberg, Germany
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Publikationsverlauf

Publikationsdatum:
05. Mai 2017 (online)

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    Background:

    Subclinical inflammation has been implicated in the development of depression, a common comorbidity of type 1 diabetes (T1D) and type 2 diabetes (T2D). This study aimed to compare the relationships of immune mediators with depressive symptoms between patients with T1D and T2D.

    Materials and methods:

    Six biomarkers of inflammation were measured in serum samples of participants with elevated depressive symptoms and T1D (n = 389, diabetes duration 15 ± 11 years) or T2D (n = 204, diabetes duration 13 ± 8 years). Subclinical depression was examined using three questionnaires (Center for Epidemiologic Studies Depression [CES-D] score, Patient Health Questionnaire [PHQ9], 5-item World Health Organization Well-Being Index [WHO5]).

    Results:

    In T1D, levels of interleukin-1 receptor antagonist (IL-1RA) were positively associated with depression for two scores (CES-D, PHQ9), high-sensitivity C-reactive protein (hsCRP) was positively associated with depression for one score (WHO5) after adjustment for age, sex, study, BMI, diabetes duration, metabolic variables, medication and comorbidities (p = 0.008 – 0.042). In T2D, IL-18 and IL-1RA were positively associated with depression for two scores (IL-18: PHQ9, WHO5; IL-1RA: CES-D, WHO5), hsCRP for one score (PHQ9), and adiponectin showed an inverse association with depression for one score (PHQ9) after adjustment (p = 0.006 – 0.048). No associations were found for IL-6 and monocyte chemoattractant protein-1 (MCP-1/CCL2).

    Conclusions:

    Associations between biomarkers of inflammation and depressive symptoms in patients with diabetes were most consistent for IL-1RA and hsCRP. In T2D, there was additional evidence for associations between IL-18 and (inversely) adiponectin with depressive symptoms. The strength of the associations depended on diabetes type and the method used to assess depressive symptoms.


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