Synlett 2017; 28(10): 1195-1200
DOI: 10.1055/s-0036-1588144
letter
© Georg Thieme Verlag Stuttgart · New York

NaI-Mediated Acetamidosulfenylation of Alkenes with Bunte Salts as Thiolating Reagent Leading to β-Acetamido Sulfides

Rongxing Zhang
a   College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, P. R. of China   Email: senlin@ncu.edu.cn
,
Zhaohua Yan
a   College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, P. R. of China   Email: senlin@ncu.edu.cn
,
Dingyi Wang
a   College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, P. R. of China   Email: senlin@ncu.edu.cn
,
Yuanxing Wang*
b   State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330031, P. R. of China   Email: yuanxingwang@ncu.edu.cn
,
Sen Lin*
a   College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, P. R. of China   Email: senlin@ncu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 05 December 2016

Accepted after revision: 14 January 2017

Publication Date:
03 February 2017 (online)

 


Abstract

A direct and efficient method for the acetamidosulfenylation reaction of alkenes was developed, in which NaI was used as a catalyst, DMSO as the oxidant, nitriles as both the solvent and nucleophiles and stable, readily available Bunte salts as thiolating reagents. The reactions were carried out under mild conditions generating β-acetamido sulfides in good yields. Moreover, the reaction can be performed when alcohols are used as nucleophiles providing the corresponding β-alkoxysulfides in moderate yields, respectively.


#

Organosulfur compounds, over the past decades, not only receive wide application in material science,[1] but also play an important role in medicinal chemistry,[2] natural products,[3] and food chemistry.[4] It is an effective strategy to obtain organosulfur products through the difunctionalization of alkenes in synthetic organic chemistry.[5] Among them, sulfenylation of alkene employing various sulfur reagents has gained great attention and progress in recent years.[6] Different sulfur sources, such as thiols,[6a] disulfides,[6b] arylsulfonyl chlorides,[6c] and arylsulfonyl cyanides,[6d] etc.,[6e] have been well developed for these transformations. However, in order to meet the requirements for multifunctionalized organosulfur compounds, simpler, more effective, and green methods for difunctionalization of alkenes are still highly desirable.

β-Acetamido sulfides, as an important member in sulfur-containing compounds, exist widely as moieties in natural products and biologically active molecules,[7] such as lactacystin,[7a] which is a proteasome inhibitor, frenolicin C[7b] with anticoccidial activity, and lucensimycin D[7c] with antibacterial activities (Figure [1]).

Zoom Image
Figure 1 Examples of β-acetamido sulfides

In the last years, the acetamidosulfenylation of alkene has emerged as a direct and efficient protocol for the synthesis of β-acetamido sulfides. Cui[8a] and Zheng,[8b] respectively, described a three-component oxidative acetamidosulfenylation of alkenes in which disulfides and thiols with unpleasant odor served as thiolating reagents (Scheme [1, a] and b).

Zoom Image
Scheme 1 Methods for acetamidosulfenylation of alkenes

Bunte salts, which can be prepared by the reaction of sodium thiosulfate with various halides, are stable, readily available, and odorless solid compounds.[9] They have been widely applied in the synthesis of organosulfur compounds.[10] In 2014, Reeves reported the synthesis of sulfides via the reaction of Grignard reagent and Bunte salts.[10a] In 2015, Yi’s group described thia-Michael addition using Bunte salts.[10b] Very recently, Luo[10c] and Ji,[10d] respectively, explored the application of Bunte salts as thiolating regents in the synthesis of 3-thioindoles. To the best of our knowledge, Bunte salts have not yet been applied in the sulfenylation reaction of alkenes.

In consideration of the fact that the odorless and stable Bunte salts can be easily converted into disulfides in solvents, we envisioned that they should be better candidates as thiolating sources for the acetamidosulfenylation of alkenes. As a continuation of our project directed toward the C–S bond formation, herein we present a direct and efficient method for the acetamidosulfenylation reaction of alkenes in which NaI was used as a catalyst, DMSO as the oxidant, nitriles as both the solvent and nucleophiles, and Bunte salts as thiolating reagents (Scheme [1, c]).

Initially, we conducted the reaction of styrene (1a, 0.30 mmol) with sodium s-benzyl thiosulfate (2a, 0.45 mmol) in the presence of (NH4)2S2O8 and iodine in acetonitrile at 80 °C for nine hours (Table [1], entry 1), but no desired product 4a was observed. It is worth noting that 4a was detected, respectively, in 56% and 58% yields when iodide salts such as NH4I and NaI were used instead of iodine in acetonitrile as solvent (Table [1], entries 3 and 4). In order to improve productivity, various oxidants for example K2S2O8, TBHP, DTBP, DDQ, and DMSO were then screened, and results indicated that DMSO was the best choice and no reaction took place when TBHP, DTBP, and DDQ were used as oxidants (Scheme [2], entries 5–9). Next, the effect of reaction temperature was explored (Table [1], entries 9–12). It was found that the yield of 4a was improved to 84% when the reaction temperature was increased to 100 °C (Table1, entry 11). Decreasing the amount of DMSO led to a negative effect and no reaction occurred without DMSO (Table [1], entries 13 and 14). Similarly, the yield of 4a decreased when reducing the loading of NaI, and the reaction did not take place at all without NaI (Table [1], entries 15 and 16). Thus, the optimized reaction conditions are as follows: alkenes (1.0 equiv), Bunte salts (1.5 equiv), H2O (2.0 equiv), NaI (20 mol%) as catalyst, DMSO (2.0 equiv) as oxidant, and nitriles as both the solvent and nucleophiles at 100 °C in a sealed tube.

Table 1 Optimization of Reaction Conditionsa

Entry

Iodide (mol%)

Oxidant (equiv)

Temp (°C)

Yield (%)b

 1

I2 (20)

(NH4)2S2O8 (2.0)

 80

n.r.

 2

TBAI (20)

(NH4)2S2O8 (2.0)

 80

trace

 3

NaI (20)

(NH4)2S2O8 (2.0)

 80

58

 4

NH4I (20)

(NH4)2S2O8 (2.0)

 80

56

 5

NaI (20)

K2S2O8 (2.0)

 80

41

 6

NaI (20)

TBHP(2.0)

 80

n.r.

 7

NaI (20)

DTBP (2.0)

 80

n.r.

 8

NaI (20)

DDQ (2.0)

 80

n.r.

 9

NaI (20)

DMSO (2.0)

 80

75

10

I2 (10)

DMSO (2.0)

 80

47

11

NaI (20)

DMSO (2.0)

 60

52

12

NaI (20)

DMSO (2.0)

100

84

13

NaI (20)

DMSO (1.0)

100

65

14

NaI (20)

100

n.r.

15

NaI (10)

DMSO (2.0)

100

74

16

DMSO (2.0)

100

n.r.

a Reaction conditions: 1a (0.30 mmol), 2a (0.45 mmol), 3a (1.5 mL), H2O (0.60 mmol), 9 h in a sealed tube.

b Yield of isolated product.

Under the optimized reaction conditions, we investigated the scope and limitation of the reaction of sodium s-benzylthiosulfate (2a) with various alkene substrates, and the results are listed in Scheme [2]. Styrenes having electron-rich groups on the benzene ring such as 4-methyl and 4-tert-butyl gave the corresponding target products in good yields(4b and 4c; Scheme [2]). The reaction of styrenes possessing electron-withdrawing groups offered the corresponding products in slightly poor 53–71% yields (4dh; Scheme [2]). Notably, the reaction of cyclohexene as aliphatic alkene with sodium s-benzyl thiosulfate (2a) also proceeds well generating 4i in good yield (4i; Scheme [2]).

Zoom Image
Scheme 2 Reagents and conditions: 1 (0.30 mmol), 2a (0.45 mmol), 3a (1.5 mL), H2O (0.60 mmol), NaI (20 mol%), 9 h in a sealed tube. Yields are for the isolated products.

Next, the participation of various Bunte salts and aryl nitriles in this protocol were studied, and the results are shown in Scheme [3]. The use of sodium s-(4-methyl)benzylthiosulfate and sodium s-benzylthiosulfates possessing electron-poor groups on benzene ring resulted in the formation of the corresponding β-acetamido sulfides in moderate yields (5bd; Scheme [3]). The yield of products slightly decreased when aryl nitriles as nucleophiles were employed, which probably resulted from steric hindrance especially in the case of 5f (5eg, Scheme [3]). On the other hand, sodium s-arylthiosulfate possessing 4-methyl on the benzene ring was used in reaction with good yield (5h; Scheme [3]), similarly, sodium s-(4-chloro)phenylthiosulfate underwent the same acetamidosulfenylation reaction with the formation of 5i in 62% yield (5i; Scheme [3]) which may be influenced by electron-poor effect. Moreover, aliphatic Bunte salt can partcipate in the reaction with good yield (5j; Scheme [3]).

Zoom Image
Scheme 3 Reagents and conditions: 1a (0.30 mmol), 2 (0.45 mmol), 3 (1.5 mL), H2O (0.60 mmol), NaI (20 mol%), 9 h in a sealed tube. Yields are for the isolated products.

Furthermore, the potential industrial application of this reaction was demonstrated on a gram scale. As shown in Scheme [4], the reaction could afford 1.62 grams of 4a in 71% yield, demonstrating the potential applications of the reaction for a large-scale synthesis of β-acetamido sulfides.

To extend the scope of sulfenylation of alkenes with Bunte salts as thiolating reagent, we tested other nucleophiles. The reactions of sodium s-benzyl thiosulfate (2a) with styrene (1a) and alcohols 6 were carried out, and the results are shown in Scheme [5]. The results show that the alkoxysulfenylation of styrene can proceed well although β-alkoxy sulfides were only obtained in moderate yields.

In order to attain further insight into the reaction mechanism, we tried three reactions as contents of control experiments, and the results are outlined in Scheme [4]. First, the reaction of 1a with 2a in the presence of 2,6-di-tert-butylphenol as free-radical inhibitor was not terminated and it still proceeds smoothly (Scheme [6], eq. 1). Sodium s-benzyl sulfothioate (2a) can be successfully transformed into dibenzyl disulfide (8a) in 95% yield under the standard conditions in the absence of NaI and DMSO (Scheme [6], eq. 2). No corresponding products were observed when sodium s-benzyl sulfothioate (2a) was replaced by dibenzyl disulfide (8a, Scheme [6], eq. 3).The above results show that the reaction mechanism of 1a with 2a might not be a radical pathway, and the disulfide might be an intermediate.

Zoom Image
Scheme 4 Gram-scale reaction
Zoom Image
Scheme 5 Reagents and conditions: 1a (0.30 mmol), 2 (0.45 mmol), 6 (100 μL), H2O (0.60 mmol), NaI (20 mol%), 9 h in air. Yields are for the isolated products.
Zoom Image
Scheme 6 Control experiments

On the basis of the reported literatures[8] , [11] [12] [13] [14] and the above results of control experiments, a plausible mechanism is depicted in Scheme [7]. Under the heating conditions, the hydrolysis of Bunte salts A in the presence of water leads to the formation of species bisulfate anion and thiol or thiol anion B in the reaction mixture.[11] The disulfide C are thus generated through the attack by thiol or thiol anion B on another Bunte salt A.[12] Next, the reaction of disulfide C with I2 to gives RSI D which is an electrophilic species,[13a] and an intermediate F appeared via the attack of alkene E by RSI D.[8a] [13b] The subsequent reaction of the intermediate F with nitriles followed by Ritter reaction, alcohol affords β-acetamido sulfides G, and β-alkoxy sulfides I with the release of HI.[14] Finally, two molecules of HI were oxidized by DMSO and transformed into molecular I2 accompanied by the formation of water and dimethyl sulfide.[13a] [15]

Zoom Image
Scheme 7 Plausible reaction mechanism

In summary, a direct and facile method has been developed for the synthesis of β-acetamido sulfides through the acetamidosulfenyation of alkenes in moderate to good yields in which odorless solid Bunte salts were used as thiolating reagents, NaI as a catalyst, DMSO as the mild oxidant, and nitriles as both the solvent and nucleophiles.[16] Furthermore, the reaction can be extended for alcohols substrate leading to the synthesis of β-alkoxy sulfides, respectively.


#

No conflict of interest has been declared by the author(s).

Acknowledgment

We are grateful for the financial support from the National Natural Science Foundation of China (21302084).

Supporting Information

  • References and Notes

    • 1a Cook S, Furube A, Katoh R. J. Mater. Chem. 2012; 22: 4282-4282
    • 1b Manthiram A, Fu YZ, Chung SH, Zu C, Su YS. Chem. Rev. 2014; 114: 11751-11751
    • 1c Je SH, Hwang TH, Talapaneni SN, Buyukcakir O, Kim HJ, Yu JS, Woo SG, Jang MC, Son BK, Coskun A, Choi JW. ACS Energy Lett. 2016; 1: 566-566
    • 2a Beno BR, Yeung KS, Bartberger MD, Pennington LD, Meanwell NA. J. Med. Chem. 2015; 58: 4383-4383
    • 2b Dahlin JL, Nissink JM, Strasser JM, Francis S, Higgins LA, Zhou H, Zhang ZG, Walters MA. J. Med. Chem. 2015; 58: 2091-2091
    • 2c Kardos J, Szabo Z, Heja L. J. Med. Chem. 2016; 59: 777-777
    • 3a Meng D, Chen WL, Zhao WM. J. Nat. Prod. 2007; 70: 824-824
    • 3b Gelais AS, Legaylt J, Mshvildadze V, Pichette A. J. Nat. Prod. 2015; 78: 1904-1904
    • 3c Hill R, Sutherland A. Nat. Prod. Rep. 2016; 33: 122-122
    • 4a Wakamatsu J, Stark TD, Hofmann T. J. Agric. Food Chem. 2016; 64: 5845-5845
    • 4b Williams KL, Tjeerdema RS. J. Agric. Food Chem. 2016; 64: 4838-4838
    • 5a Jensen KH, Webb JD, Sigman MS. J. Am. Chem. Soc. 2010; 132: 17471-17471
    • 5b Ricci P, Khotavivattana T, Pfeifer L, Médebielle M, Morphy JR, Gouverneur V. Chem. Sci. 2017; 8: 1195-1195
    • 6a Fang ZS, Qiang PX, Hao Z, Adedamola S, Ping ZJ. J. Org. Chem. 2015; 7: 3682-3682
    • 6b Vieira AA, Azeredo JB, Godoi M, Santi C, Junior EN. S, Braga AL. J. Org. Chem. 2015; 80: 2120-2120
    • 6c Wang DY, Zhang RX, Lin S, Yan ZH, Guo SM. Synlett 2016; 27: 2003-2003
    • 6d Yang FL, Wang FX, Wang TT, Wang YJ, Tian SK. Chem. Commun. 2014; 17: 2111-2111
    • 6e Wei W, Wen JW, Yang DS, Wu M, You JM, Wang H. Org. Biomol. Chem. 2014; 39: 7678-7678
    • 7a Gu WX, Silverman RB. J. Org. Chem. 2011; 76: 8287-8287
    • 7b Wang XC, Shaaban KA, Elshahawi SI, Ponomareva LV, Sunkara M, Zhang YN, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. J. Nat. Prod. 2013; 76: 1441-1441
    • 7c Singh SB, Zink DL, Dorso K, Motyl M, Salazar O, Basilio A, Vicente F, Byrne KM, Ha S, Genilloud O. J. Nat. Prod. 2009; 72: 345-345
    • 8a Cui HH, Liu XX, Wei W, Yang DS, He CL, Zhang TT, Wang H. J. Org. Chem. 2016; 81: 2252-2252
    • 8b Zheng Y, He Y, Rong GW, Zhang XL, Weng YC, Dong KY, Xu XF, Mao JC. Org. Lett. 2015; 17: 5444-5444
    • 9a Bunte H. Chem. Ber. 1874; 7: 646-646
    • 9b Distler H. Angew. Chem., Int. Ed. Engl. 1967; 6: 544-544
    • 10a Reeves JT, Camara K, Han ZS, Xu Y, Lee H, Busacca CA, Senanayake CH. Org. Lett. 2014; 16: 1196-1196
    • 10b Ding YC, Xie P, Zhu WH, Xu BJ, Zhao WN, Zhou AH. RSC Adv. 2015; 5: 31347-31347
    • 10c Qi H, Zhang TX, Wan KF, Luo MM. J. Org. Chem. 2016; 81: 4262-4262
    • 10d Li J, Cai ZJ, Wang SY, Ji SJ. Org. Biomol. Chem. 2016; 14: 9384-9384
  • 11 Abbasi M, Mohammadizadeh MR, Saeedi N. New J. Chem. 2016; 40: 89-89
  • 12 Milligan B, Savillea B, Swan JM. J. Chem. Soc. 1961; 4850-4850
    • 13a Parumala SK. R, Peddinti RK. Green Chem. 2015; 17: 4068-4068
    • 13b Schmid GH, Garratt DG. Tetrahedron Lett. 1983; 24: 5299-5299
    • 14a Hari DP, Hering T, Konig B. Angew. Chem. Int. Ed. 2014; 53: 725-725
    • 14b Luo J, Zhu Z, Liu Y, Zhao X. Org. Lett. 2015; 17: 3620-3620
    • 15a Yang DS, Sun PF, Wei W, Meng LD, He LC, Fang BK, Jiang W, Wang H. Org. Chem. Front. 2016; 3: 1457-1457
    • 15b Azeredo JB, Godoi M, Martins GM, Silveira CC, Braga AL. J. Org. Chem. 2014; 79: 4125-4125
  • 16 General Procedure for the Synthesis of Compound 4 or 5 NaI (0.06 mmol), H2O (0.60 mmol) and Bunte salt 2 (0.45 mmol) were added to a solution of nitrile 3 containing alkene 1 (0.30 mmol), followed by the addition of DMSO (0.60 mmol). The reaction mixture was stirred in a sealed tube at 100 °C for 9 h. After completion of the reaction, the reaction mixture was diluted with EtOAc, and quenched with sat. Na2S2O3 solution and extracted with EtOAc (3 × 10 mL). The organic layer was washed with water and dried over anhydrous Na2SO4. The solvent was evaporated in vacuo, and the residue was subjected to column chromatography using EtOAc in PE as the eluent to afford the pure target product 4 or 5. Compound 4b was obtained in 82% yield (73.7 mg) according to the general procedure for the synthesis of 4 as a white solid. 1H NMR (400 MHz, CDCl3): δ = 7.32–7.23 (m, 5 H), 7.12 (s, 4 H), 6.03 (d, J = 8.0 Hz, 1 H), 5.12 (q, J = 8.0 Hz, 1 H), 3.59 (q, J = 12 Hz, 2 H), 2.86–2.74 (m, 2 H), 2.32 (s, 3 H), 1.95 (s, 3 H). 13C NMR (100 MHz, CDCl3): δ = 169.5, 138.0, 137.7, 137.4, 129.4, 129.0, 128.5, 127.1, 125.4, 51.8, 37.1, 36.4, 23.4, 21.1. ESI-HRMS: m/z calcd for C18H21NOS [M + Cl]+: 334.1027; found: 334.1036. General Procedure for the Synthesis of Compound 7 NaI (0.06 mmol) and 2a (0.45 mmol) was added to a solution of acetonitrile 3a containing styrene 1a (0.30 mmol) and alcohol (100 μL) or 2-allylphenol 6d (0.3 mmol), followed by DMSO (0.60 mmol). The reaction mixture was stirred at 90 °C for 6–9 h. After completion of the reaction, the reaction mixture was diluted with EtOAc, quenched with sat. Na2S2O3 solution and extracted twice with EtOAc (2 × 15 mL). The organic layer was washed with water and dried over anhydrous Na2SO4. The solvent was evaporated in vacuo, and the residue was subjected to column chromatography using EtOAc in PE as the eluent to afford the pure target product 7.Compound 7a was obtained in 42% yield (32.7 mg) according to the general procedure for the synthesis of 7 as a colorless liquid. 1H NMR (400 MHz, CDCl3): δ = 7.37–7.21 (m, 10 H), 4.31 (q, J = 8.0 Hz, 1 H), 3.69 (q, J = 12.0 Hz, 1 H), 3.42–3.33 (m, 1 H), 2.84 (q, J = 8.0 Hz, 1 H), 2.60 (q, J = 8.0 Hz, 1 H), 1.20 (t, J =8.0 Hz, 3 H). 13C NMR (100 MHz, CDCl3): δ = 141.6, 138.6, 129.0, 129.4, 128.4, 128.4, 127.8, 126.9, 126.7, 82.3, 64.5, 38.7, 37.2, 15.3. ESI-HRMS: m/z calcd for C17H20OS [M + Na]+: 295.1127; found: 295.1120.

  • References and Notes

    • 1a Cook S, Furube A, Katoh R. J. Mater. Chem. 2012; 22: 4282-4282
    • 1b Manthiram A, Fu YZ, Chung SH, Zu C, Su YS. Chem. Rev. 2014; 114: 11751-11751
    • 1c Je SH, Hwang TH, Talapaneni SN, Buyukcakir O, Kim HJ, Yu JS, Woo SG, Jang MC, Son BK, Coskun A, Choi JW. ACS Energy Lett. 2016; 1: 566-566
    • 2a Beno BR, Yeung KS, Bartberger MD, Pennington LD, Meanwell NA. J. Med. Chem. 2015; 58: 4383-4383
    • 2b Dahlin JL, Nissink JM, Strasser JM, Francis S, Higgins LA, Zhou H, Zhang ZG, Walters MA. J. Med. Chem. 2015; 58: 2091-2091
    • 2c Kardos J, Szabo Z, Heja L. J. Med. Chem. 2016; 59: 777-777
    • 3a Meng D, Chen WL, Zhao WM. J. Nat. Prod. 2007; 70: 824-824
    • 3b Gelais AS, Legaylt J, Mshvildadze V, Pichette A. J. Nat. Prod. 2015; 78: 1904-1904
    • 3c Hill R, Sutherland A. Nat. Prod. Rep. 2016; 33: 122-122
    • 4a Wakamatsu J, Stark TD, Hofmann T. J. Agric. Food Chem. 2016; 64: 5845-5845
    • 4b Williams KL, Tjeerdema RS. J. Agric. Food Chem. 2016; 64: 4838-4838
    • 5a Jensen KH, Webb JD, Sigman MS. J. Am. Chem. Soc. 2010; 132: 17471-17471
    • 5b Ricci P, Khotavivattana T, Pfeifer L, Médebielle M, Morphy JR, Gouverneur V. Chem. Sci. 2017; 8: 1195-1195
    • 6a Fang ZS, Qiang PX, Hao Z, Adedamola S, Ping ZJ. J. Org. Chem. 2015; 7: 3682-3682
    • 6b Vieira AA, Azeredo JB, Godoi M, Santi C, Junior EN. S, Braga AL. J. Org. Chem. 2015; 80: 2120-2120
    • 6c Wang DY, Zhang RX, Lin S, Yan ZH, Guo SM. Synlett 2016; 27: 2003-2003
    • 6d Yang FL, Wang FX, Wang TT, Wang YJ, Tian SK. Chem. Commun. 2014; 17: 2111-2111
    • 6e Wei W, Wen JW, Yang DS, Wu M, You JM, Wang H. Org. Biomol. Chem. 2014; 39: 7678-7678
    • 7a Gu WX, Silverman RB. J. Org. Chem. 2011; 76: 8287-8287
    • 7b Wang XC, Shaaban KA, Elshahawi SI, Ponomareva LV, Sunkara M, Zhang YN, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. J. Nat. Prod. 2013; 76: 1441-1441
    • 7c Singh SB, Zink DL, Dorso K, Motyl M, Salazar O, Basilio A, Vicente F, Byrne KM, Ha S, Genilloud O. J. Nat. Prod. 2009; 72: 345-345
    • 8a Cui HH, Liu XX, Wei W, Yang DS, He CL, Zhang TT, Wang H. J. Org. Chem. 2016; 81: 2252-2252
    • 8b Zheng Y, He Y, Rong GW, Zhang XL, Weng YC, Dong KY, Xu XF, Mao JC. Org. Lett. 2015; 17: 5444-5444
    • 9a Bunte H. Chem. Ber. 1874; 7: 646-646
    • 9b Distler H. Angew. Chem., Int. Ed. Engl. 1967; 6: 544-544
    • 10a Reeves JT, Camara K, Han ZS, Xu Y, Lee H, Busacca CA, Senanayake CH. Org. Lett. 2014; 16: 1196-1196
    • 10b Ding YC, Xie P, Zhu WH, Xu BJ, Zhao WN, Zhou AH. RSC Adv. 2015; 5: 31347-31347
    • 10c Qi H, Zhang TX, Wan KF, Luo MM. J. Org. Chem. 2016; 81: 4262-4262
    • 10d Li J, Cai ZJ, Wang SY, Ji SJ. Org. Biomol. Chem. 2016; 14: 9384-9384
  • 11 Abbasi M, Mohammadizadeh MR, Saeedi N. New J. Chem. 2016; 40: 89-89
  • 12 Milligan B, Savillea B, Swan JM. J. Chem. Soc. 1961; 4850-4850
    • 13a Parumala SK. R, Peddinti RK. Green Chem. 2015; 17: 4068-4068
    • 13b Schmid GH, Garratt DG. Tetrahedron Lett. 1983; 24: 5299-5299
    • 14a Hari DP, Hering T, Konig B. Angew. Chem. Int. Ed. 2014; 53: 725-725
    • 14b Luo J, Zhu Z, Liu Y, Zhao X. Org. Lett. 2015; 17: 3620-3620
    • 15a Yang DS, Sun PF, Wei W, Meng LD, He LC, Fang BK, Jiang W, Wang H. Org. Chem. Front. 2016; 3: 1457-1457
    • 15b Azeredo JB, Godoi M, Martins GM, Silveira CC, Braga AL. J. Org. Chem. 2014; 79: 4125-4125
  • 16 General Procedure for the Synthesis of Compound 4 or 5 NaI (0.06 mmol), H2O (0.60 mmol) and Bunte salt 2 (0.45 mmol) were added to a solution of nitrile 3 containing alkene 1 (0.30 mmol), followed by the addition of DMSO (0.60 mmol). The reaction mixture was stirred in a sealed tube at 100 °C for 9 h. After completion of the reaction, the reaction mixture was diluted with EtOAc, and quenched with sat. Na2S2O3 solution and extracted with EtOAc (3 × 10 mL). The organic layer was washed with water and dried over anhydrous Na2SO4. The solvent was evaporated in vacuo, and the residue was subjected to column chromatography using EtOAc in PE as the eluent to afford the pure target product 4 or 5. Compound 4b was obtained in 82% yield (73.7 mg) according to the general procedure for the synthesis of 4 as a white solid. 1H NMR (400 MHz, CDCl3): δ = 7.32–7.23 (m, 5 H), 7.12 (s, 4 H), 6.03 (d, J = 8.0 Hz, 1 H), 5.12 (q, J = 8.0 Hz, 1 H), 3.59 (q, J = 12 Hz, 2 H), 2.86–2.74 (m, 2 H), 2.32 (s, 3 H), 1.95 (s, 3 H). 13C NMR (100 MHz, CDCl3): δ = 169.5, 138.0, 137.7, 137.4, 129.4, 129.0, 128.5, 127.1, 125.4, 51.8, 37.1, 36.4, 23.4, 21.1. ESI-HRMS: m/z calcd for C18H21NOS [M + Cl]+: 334.1027; found: 334.1036. General Procedure for the Synthesis of Compound 7 NaI (0.06 mmol) and 2a (0.45 mmol) was added to a solution of acetonitrile 3a containing styrene 1a (0.30 mmol) and alcohol (100 μL) or 2-allylphenol 6d (0.3 mmol), followed by DMSO (0.60 mmol). The reaction mixture was stirred at 90 °C for 6–9 h. After completion of the reaction, the reaction mixture was diluted with EtOAc, quenched with sat. Na2S2O3 solution and extracted twice with EtOAc (2 × 15 mL). The organic layer was washed with water and dried over anhydrous Na2SO4. The solvent was evaporated in vacuo, and the residue was subjected to column chromatography using EtOAc in PE as the eluent to afford the pure target product 7.Compound 7a was obtained in 42% yield (32.7 mg) according to the general procedure for the synthesis of 7 as a colorless liquid. 1H NMR (400 MHz, CDCl3): δ = 7.37–7.21 (m, 10 H), 4.31 (q, J = 8.0 Hz, 1 H), 3.69 (q, J = 12.0 Hz, 1 H), 3.42–3.33 (m, 1 H), 2.84 (q, J = 8.0 Hz, 1 H), 2.60 (q, J = 8.0 Hz, 1 H), 1.20 (t, J =8.0 Hz, 3 H). 13C NMR (100 MHz, CDCl3): δ = 141.6, 138.6, 129.0, 129.4, 128.4, 128.4, 127.8, 126.9, 126.7, 82.3, 64.5, 38.7, 37.2, 15.3. ESI-HRMS: m/z calcd for C17H20OS [M + Na]+: 295.1127; found: 295.1120.

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Figure 1 Examples of β-acetamido sulfides
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Scheme 1 Methods for acetamidosulfenylation of alkenes
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Scheme 2 Reagents and conditions: 1 (0.30 mmol), 2a (0.45 mmol), 3a (1.5 mL), H2O (0.60 mmol), NaI (20 mol%), 9 h in a sealed tube. Yields are for the isolated products.
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Scheme 3 Reagents and conditions: 1a (0.30 mmol), 2 (0.45 mmol), 3 (1.5 mL), H2O (0.60 mmol), NaI (20 mol%), 9 h in a sealed tube. Yields are for the isolated products.
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Scheme 4 Gram-scale reaction
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Scheme 5 Reagents and conditions: 1a (0.30 mmol), 2 (0.45 mmol), 6 (100 μL), H2O (0.60 mmol), NaI (20 mol%), 9 h in air. Yields are for the isolated products.
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Scheme 6 Control experiments
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Scheme 7 Plausible reaction mechanism