Int J Angiol 2017; 26(01): 027-031
DOI: 10.1055/s-0036-1587695
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Competitive Coronary Flow between the Native Left Anterior Descending Artery and Left Internal Mammary Artery Graft: Is It a Surrogate Angiographic Marker of Over-or-Unnecessary Revascularization Decision in Daily Practice?

Pinar Dogan*
1   Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey
2   Cardiology Clinic, Aksaray State Hospital, Aksaray, Turkey
,
Mevlut Serdar Kuyumcu*
1   Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey
,
Emine Demiryapan
1   Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey
,
Fazil Arisoy
1   Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey
,
Ozcan Ozeke
1   Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
05 September 2016 (online)

Abstract

Overdiagnosis and overtreatment are often thought of as relatively recent phenomena in modern medicine, influenced by a contemporary combination of technology, specialization, payment models, marketing, and supply-related demand. Several investigators have reported discrepancies between the angiographic and functional severity of coronary angiographic stenosis. However, the visual anatomic assessment of the coronary lesion severity continues in daily practice.

We evaluated the consecutive all coronary angiograms performed between January 2015 and December 2015 and examined only patients who had previous coronary artery bypass grafting (CABG) to analyze the cases with regard to presence of the competitive flow (CF) between the native left anterior descending coronary artery (LAD) and left internal mammary artery (LIMA) graft.

A total of 8,248 diagnostic coronary angiographies were performed between January 2015 and December 2015 at our facility. Of these, 886 coronary angiographies of CABG patients were detected. Whereas LIMA graft occlusion detected in 19 patient (2.1%), the LIMA-LAD CF rate was found in 86 (9.7%) CABG patients. The angiographic severity of the LAD stenosis in CF group evaluated as mild in 20 (25%), moderate in 61 (70%), and severe coronary artery disease in 4 (5%) patients.

Our results showed that there is 9.7% rate of LIMA-LAD CF. Therefore, some unnecessary coronary stenting or CABG procedures might have been performed due to limited use of functional testing for clinical decision making. The functional angiography should play a more prominent role in catheterization laboratories as recommended by current revascularization guidelines to prevent overdiagnosis, misdiagnosis, or incorrect treatment decisions.

* Both the authors contributed equally to this work.


 
  • References

  • 1 Chan PS, Patel MR, Klein LW , et al. Appropriateness of percutaneous coronary intervention. JAMA 2011; 306 (1) 53-61
  • 2 Park SJ, Ahn JM, Kang SJ. Paradigm shift to functional angioplasty: new insights for fractional flow reserve- and intravascular ultrasound-guided percutaneous coronary intervention. Circulation 2011; 124 (8) 951-957
  • 3 Campbell PT, Mahmud E, Marshall JJ. Interoperator and intraoperator (in)accuracy of stent selection based on visual estimation. Catheter Cardiovasc Interv 2015; 86 (7) 1177-1183
  • 4 Pijls NH, van Schaardenburgh P, Manoharan G , et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER study. J Am Coll Cardiol 2007; 49 (21) 2105-2111
  • 5 Pijls NH, Fearon WF, Tonino PA , et al; FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional flow reserve versus angiography for multivessel evaluation) study. J Am Coll Cardiol 2010; 56 (3) 177-184
  • 6 Lin GA, Dudley RA, Lucas FL, Malenka DJ, Vittinghoff E, Redberg RF. Frequency of stress testing to document ischemia prior to elective percutaneous coronary intervention. JAMA 2008; 300 (15) 1765-1773
  • 7 Kolata G. Some bypass surgery unnecessary. Results from an NHLBI clinical trial suggest that 25,000 potential bypass patients should not have the surgery. Science 1983; 222 (4624): 605
  • 8 Botman CJ, Schonberger J, Koolen S , et al. Does stenosis severity of native vessels influence bypass graft patency? A prospective fractional flow reserve-guided study. Ann Thorac Surg 2007; 83 (6) 2093-2097
  • 9 Taggart DP. Current status of arterial grafts for coronary artery bypass grafting. Ann Cardiothorac Surg 2013; 2 (4) 427-430
  • 10 Sabik III JF, Blackstone EH. Coronary artery bypass graft patency and competitive flow. J Am Coll Cardiol 2008; 51 (2) 126-128
  • 11 Nakajima H, Kobayashi J, Tagusari O , et al. Angiographic flow grading and graft arrangement of arterial conduits. J Thorac Cardiovasc Surg 2006; 132 (5) 1023-1029
  • 12 Tonino PA, Fearon WF, De Bruyne B , et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol 2010; 55 (25) 2816-2821
  • 13 Nakajima H, Kobayashi J, Toda K , et al. A 10-year angiographic follow-up of competitive flow in sequential and composite arterial grafts. Eur J Cardiothorac Surg 2011; 40 (2) 399-404
  • 14 Glineur D, Hanet C. Competitive flow in coronary bypass surgery: is it a problem?. Curr Opin Cardiol 2012; 27 (6) 620-628
  • 15 Sabik III JF, Lytle BW, Blackstone EH, Khan M, Houghtaling PL, Cosgrove DM. Does competitive flow reduce internal thoracic artery graft patency?. Ann Thorac Surg 2003; 76 (5) 1490-1496 , discussion 1497
  • 16 Bolotin G, Kypson AP, Nifong LW, Chitwood Jr WR. A technique for evaluating competitive flow for intraoperative decision making in coronary artery surgery. Ann Thorac Surg 2003; 76 (6) 2118-2120
  • 17 Nakajima H, Iguchi A, Tabata M , et al. Predictors and prevention of flow insufficiency due to limited flow demand. J Cardiothorac Surg 2014; 9 (1) 188
  • 18 Isner JM, Kishel J, Kent KM, Ronan Jr JA, Ross AM, Roberts WC. Accuracy of angiographic determination of left main coronary arterial narrowing. Angiographic—histologic correlative analysis in 28 patients. Circulation 1981; 63 (5) 1056-1064
  • 19 Edris A, Patel PM, Kern MJ. Early recognition of catheter-induced left main coronary artery vasospasm: implications for revascularization. Catheter Cardiovasc Interv 2010; 76 (2) 304-307
  • 20 Mohammed AA, Yang A, Shao K , et al. Patients with left main coronary artery vasospasm inadvertently undergoing coronary artery bypass grafting surgery. J Am Coll Cardiol 2013; 61 (8) 899-900
  • 21 Kalaga R, Uretsky BF, Sachdeva R. Atresia of the left internal mammary artery graft following percutaneous intervention of the left main. J Invasive Cardiol 2011; 23 (12) E284-E287
  • 22 Toth GG, Toth B, Johnson NP , et al. Revascularization decisions in patients with stable angina and intermediate lesions: results of the international survey on interventional strategy. Circ Cardiovasc Interv 2014; 7 (6) 751-759
  • 23 Nallamothu BK, Spertus JA, Lansky AJ , et al. Comparison of clinical interpretation with visual assessment and quantitative coronary angiography in patients undergoing percutaneous coronary intervention in contemporary practice: the Assessing Angiography (A2) project. Circulation 2013; 127 (17) 1793-1800
  • 24 De Bruyne B, Fearon WF, Pijls NH , et al; FAME 2 Trial Investigators. Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med 2014; 371 (13) 1208-1217
  • 25 Tonino PA, De Bruyne B, Pijls NH , et al; FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 2009; 360 (3) 213-224
  • 26 Chan PS, Rao SV, Bhatt DL , et al. Patient and hospital characteristics associated with inappropriate percutaneous coronary interventions. J Am Coll Cardiol 2013; 62 (24) 2274-2281
  • 27 Boden WE, O'Rourke RA, Teo KK , et al; COURAGE Trial Research Group. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007; 356 (15) 1503-1516
  • 28 Moses JW, Stone GW, Nikolsky E , et al. Drug-eluting stents in the treatment of intermediate lesions: pooled analysis from four randomized trials. J Am Coll Cardiol 2006; 47 (11) 2164-2171
  • 29 Desai NR, Bradley SM, Parzynski CS , et al. Appropriate use criteria for coronary revascularization and trends in utilization, patient selection, and appropriateness of percutaneous coronary intervention. JAMA 2015; 314 (19) 2045-2053
  • 30 Nam CW, Yoon HJ, Cho YK , et al. Outcomes of percutaneous coronary intervention in intermediate coronary artery disease: fractional flow reserve-guided versus intravascular ultrasound-guided. JACC Cardiovasc Interv 2010; 3 (8) 812-817