J Neurol Surg B Skull Base 2016; 77(02): 169-172
DOI: 10.1055/s-0036-1579545
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Definitive Radiotherapy for Skin and Adenoid Cystic Carcinoma with Perineural Invasion

William M. Mendenhall
1   Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, United States
,
Roi Dagan
1   Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, United States
,
Curtis M. Bryant
1   Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, United States
,
Robert J. Amdur
1   Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, United States
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2016 (online)

Abstract

Adenoid cystic carcinomas (ACC) and, to a lesser extent, cutaneous squamous cell carcinomas and basal cell carcinomas may exhibit perineural invasion (PNI). A subset of patients have tumors with extensive PNI tracking to the skull base that are incompletely resectable and are treated with definitive radiotherapy (RT). RT may be administered with intensity-modulated RT or proton RT. Patients with ACC may also be considered for neutron RT, although the number of available neutron facilities is limited. A substantial proportion of patients with incompletely resectable ACCs and cutaneous carcinomas may be cured with definitive RT. Proton RT provides a more conformal dose distribution compared with other modalities and is likely associated with a lower risk of complications.

 
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