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J Reconstr Microsurg 2016; 32(05): 395-401
DOI: 10.1055/s-0036-1571348
Original Article: WSRM 2015 Scientific Paper
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effects of Bezafibrate on the Survival of Random Skin Flaps in Rats

Bin Lin
1   Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical University of Wenzhou Medical University, Wenzhou, China
2   Department of Pharmacy, Changxing People's Hospital, Changxing, China
,
Yuting Lin
1   Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical University of Wenzhou Medical University, Wenzhou, China
3   Department of Hand and Plastic Surgery, The Renji College of Wenzhou Medical University, Wenzhou, China
,
Dingsheng Lin
1   Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical University of Wenzhou Medical University, Wenzhou, China
,
Bin Cao
1   Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical University of Wenzhou Medical University, Wenzhou, China
› Author Affiliations
Further Information

Publication History

27 July 2015

17 December 2015

Publication Date:
12 February 2016 (online)

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Abstract

Background Bezafibrate is widely used in clinics for its comparable angiogenic effect. Our research is to investigate the effect of bezafibrate on random skin flap survival.

Materials and Methods The “McFarlane flap” rat models were established in 30 male Sprague-Dawley rats which were divided into two groups. The treatment group was given bezafibrate (400 mg/kg/day; gavage administration), and the control group received the vehicle. The flap surviving area was measured after 7 days, and the tissue samples were taken for histological analysis and edema measurement. Vascular endothelial growth factor (VEGF) was determined using immunohistochemical methods. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were examined with kits.

Results Seven days after the operation, the surviving area in the treatment group was larger than in the control group (p < 0.01). The expression of VEGF was increased in the treatment group compared with that in the control group. And the activity of SOD was lower in the treatment group compared with those in the control group (p < 0.01). However, tissue edema, inflammatory cell infiltration, and MDA level were markedly lower in the treatment group than those in the control group (p < 0.01).

Conclusion Bezafibrate improves the survival of random skin flaps effectively.

Keywords

bezafibrate - random skin flap - survival

Note

Bin Lin and Yuting Lin contributed equally to this work.


 

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