Semin Liver Dis 2015; 35(04): 450-456
DOI: 10.1055/s-0035-1568986
Diagnostic Problems in Hepatology
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Hepatocellular Carcinoma in Noncirrhotic Liver with Glycogenotic Foci: Basic Science Meets Genomic Medicine

Jay H. Lefkowitch
1   Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York
,
Stephen M. Lagana
1   Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York
,
Tomoaki Kato
2   Department of Surgery (Liver Division) and Center for Liver Disease and Transplantation, Columbia University Medical Center, New York, New York
› Author Affiliations
Further Information

Publication History

Publication Date:
16 December 2015 (online)

Abstract

During the past decade, the application of genomic analysis to liver tumors has provided extensive data concerning tumor phenotypes, signatures, outcomes, and prognosis. In this report the authors describe a middle-aged man without known risk factors for liver disease or hepatocellular carcinoma (HCC) who developed a 19-cm HCC in his right lobe. The underlying liver was normal histologically except for multifocal glycogenotic foci similar to those found in experimental chemical carcinogenesis. Precision genomic analysis of this tumor disclosed five alterations with amplifications of genes CCNE1, FGF3 and FGF4, MYCL1, and ARID1A. The roles of these gene mutations and their potential effects in carcinogenesis in this case are discussed.

 
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