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Am J Perinatol 2016; 33(04): 329-338
DOI: 10.1055/s-0035-1564881
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Rising Burden of Preeclampsia in the United States Impacts Both Maternal and Child Health

Tiffany Shih
1   Precision Health Economics, Los Angeles, California
,
Desi Peneva
1   Precision Health Economics, Los Angeles, California
,
Xiao Xu
2   Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
,
Amelia Sutton
3   The Maternal–Fetal Medicine Division, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama
,
Elizabeth Triche
4   Neuroscience Research Mandell Center for Multiple Sclerosis and Neuroscience Research, Mount Sinai Rehabilitation Hospital, Hartford, Connecticut
,
Richard A. Ehrenkranz
2   Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
,
Michael Paidas
2   Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
,
Warren Stevens
1   Precision Health Economics, Los Angeles, California
› Author Affiliations
Further Information

Publication History

19 June 2015

05 September 2015

Publication Date:
19 October 2015 (online)

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Abstract

Objective Preeclampsia is one of the top six causes of maternal mortality in the United States (US) and is associated with considerable perinatal morbidity and mortality. Evidence suggests the US incidence of preeclampsia has increased dramatically over the past two decades. This study aims to compile, summarize, and critique the literature on the health and economic burden of preeclampsia and early-onset preeclampsia.

Study Design We reviewed the literature for estimates of burden of preeclampsia and early-onset preeclampsia to both mother and child, summarized the evidence on economic and social burden, and highlighted current gaps in the literature.

Results No recent studies comprehensively assess the costs and health consequences of preeclampsia or early-onset preeclampsia for both mother and child. Where it exists, the literature suggests preeclampsia and early-onset preeclampsia cause numerous adverse health consequences, but these conditions currently lack effective treatment. The need for preterm delivery from early-onset preeclampsia suggests its costs are substantial: very (28–31 weeks) and extremely (<28 weeks) preterm birth cost approximately 40 and 100 times a term pregnancy, respectively.

Conclusion Given the severity of outcomes from preeclampsia, further research on its health and economic consequences is essential to inform policy and resource allocation decisions in health care.

Keywords

preeclampsia - maternal and child health - burden of disease - gestational age
 

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