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Planta Med 2015; 81(18): 1712-1718
DOI: 10.1055/s-0035-1557743
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Four New Amaryllidaceae Alkaloids from Lycoris radiata and Their Cytotoxicity

Song Ang   *
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China
,
Xia-Mei Liu   *
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China
,
Xiao-Jun Huang
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China
,
Dong-Mei Zhang
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
,
Wei Zhang
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
,
Lei Wang
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China
,
Wen-Cai Ye
1   Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China
2   JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China
› Author Affiliations
Further Information

Publication History

received 27 December 2014
revised 05 June 2015

accepted 10 June 2015

Publication Date:
07 August 2015 (online)

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Abstract

Four new Amaryllidaceae alkaloids, named lycoranines C–F (1–4), together with seven known ones (5–11) were isolated from the bulbs of Lycoris radiata. Their structures with absolute configurations were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, circular dichroism spectra, modified Mosherʼs method, and molecular modeling calculation. Compounds 6, 7, 10, and 11 exhibited a potent inhibitory effect on A549 and LoVo cells with IC50 values ranging from 3.97 ± 0.36 to 17.37 ± 1.57 µM.

Key words

Lycoris radiata - Amaryllidaceae - Amaryllidaceae alkaloid - cytotoxic activity

* These authors contributed equally to this work.


Supporting Information

 

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