Int J Sports Med 2016; 37(01): 19-24
DOI: 10.1055/s-0035-1554641
Training & Testing
© Georg Thieme Verlag KG Stuttgart · New York

Acute, Low-dose CO Inhalation does not Alter Energy Expenditure during Submaximal Exercise

L. A. Kane
1   Department of Integrative Physiology, University of Colorado Boulder, Boulder, United States
,
B. J. Ryan
1   Department of Integrative Physiology, University of Colorado Boulder, Boulder, United States
,
W. Schmidt
2   Sports Medicine/Sports Physiology, University of Bayreuth, Bayreuth, Germany
,
W. C. Byrnes
1   Department of Integrative Physiology, University of Colorado Boulder, Boulder, United States
› Author Affiliations
Further Information

Publication History



accepted after revision 06 May 2015

Publication Date:
28 October 2015 (online)

Abstract

Carbon monoxide, a gas known most widely for its toxic effects at high doses, is receiving increased attention for its role as a physiological signaling molecule and potential therapeutic agent when administered in low doses. We sought to quantify any changes to oxygen consumption and energy expenditure during submaximal exercise after low-dose CO inhalation. 9 active individuals completed 4 graded submaximal exercise tests, with each test occurring during a separate visit. For their first exercise test, subjects inhaled CO or room air (1.2 mL·kg−1 body mass) in a randomized, subject-blind fashion. A second test was repeated 24 h later when the inhaled gas should have cleared the system. Subjects repeated study procedures with the alternate dose after a washout period of at least 2 days. Low-dose CO administration did not affect oxygen consumption or energy expenditure during submaximal exercise immediately or 24 h following its administration. Increases in heart rate, blood [lactate], and perceived exertion were observed following acute CO inhalation but these effects were absent after 24 h. The results of this study suggest that low-dose CO administration does not influence the energetics of submaximal exercise, but it acutely increases the relative intensity associated with absolute workloads below the lactate threshold.

 
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