Nahrungsmittel-Unverträglichkeit verstehen!

Fehlfunktionen des angeborenen Immunsystems scheinen einen entscheidenden Einfluss auf die Entstehung vieler chronischer und ernährungsbedingter Erkrankungen (u. a. Metabolisches Syndrom, peridontale Erkrankungen) zu haben. Die Aktivierung des angeborenen Immunsystems erfolgt z. B. durch Nahrungsmittel und Chemikalien, wodurch es zur Auslösung einer entzündlichen Kaskade kommt – dies kann sich als Nahrungsmittel-Unverträglichkeit und Chemikalien-Überempfindlichkeit im Organismus manifestieren.

• Literatur

• 1 Scardina GA, Messina P. Good Oral Health and Diet. Journal of Biomedicine and Biotechnology 2012; Article ID 720692
• 2 Petersen PE, Ogawa H. The global burden of periodontal disease: towards integration with chronic disease prevention and control. Periodontol 2000. 2012; 60: 15-39.
• 3 Pradeu T, Cooper EL. The danger theory: 20 years later. Front Immunol 2012; 3: 287
• 4 Hou W, Zhang Q, Yan Z et al. Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis 2013; 4: e966
• 5 Lamkanfi M, Dixit VM. Modulation of inflammasome pathways by bacterial and viral pathogens. J Immunol 2011; 187: 597-602
• 6 Chen GY, Nunez G. Inflammasomes in intestinal inflammation and cancer. Gastroenterology 2011; 141: 1986-1999
• 7 Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140: 821-832
• 8 McGettrick AF, O’Neill LA. How metabolism generates signals during innate immunity and inflammation. J Biol Chem 2013; 288: 22893-22898
• 9 Cekici A, Kantarci A, Hasturk H et al. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000 2014; 64: 57-80
• 10 Nascimento GG, Leite FR, Correa MB et al. Relationship between periodontal disease and obesity: the role of life-course events. Braz Dent J 2014; 25: 87-89
• 11 Bostanci N, Emingil G, Saygan B et al. Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. Clin Exp Immunol 2009; 157: 415-422
• 12 Sapone A, Lammers KM, Casolaro V et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med 2011; 9: 23
• 13 Fell P, Soulsby S, Brostoff J. Cellular responses to food in irritable Bowel Syndrome – an investigation of the Alcat test. Journal of Nutritional Medicine 1991; 2: 143-149
• 14 Mylek D.. ALCAT Test results in the treatment of respiratory and gastrointestinal symptoms, arthritis, skin and central nervous system. Rocz Akad Med Bialymst 1995; 40: 625-629
• 15 Dickerson F, Stallings C, Origoni A et al. Markers of gluten sensitivity in acute mania: a longitudinal study. Psychiatry Res 2012; 196: 68-71
• 16 Rashtak S, Rashtak S, Snyder MR et al. Serology of celiac disease in gluten-sensitive ataxia or neuropathy: role of deamidated gliadin antibody. J Neuroimmunol 2011; 230: 130-134
• 17 Vitte J, Michel BF, Bongrand P et al. Oxidative stress level in circulating neutrophils is linked to neurodegenerative diseases. J Clin Immunol 2004; 24: 683-692
• 18 Jyonouchi H. Food allergy and autism spectrum disorders: is there a link?. Curr Allergy Asthma Rep 2009; 9: 194-201
• 19 Holgate ST. Innate and adaptive immune responses in asthma. Nat Med 2012; 18: 673-683
• 20 Akmal M, Khan S, Khan A. The Effect of the ALCAT Test Diet Therapy for Food Sensitivity in Patient’s With Obesity. Middle East Journal of Family Medicine 2009; 7
• 21 Oodegard JL, Chawla A. Connecting Type 1 and Type 2 Diabetes through innate immunity. Cold Spring Harb Perspect Med 2012; 2: a007724
• 22 Bastard JP, Maachi M, Lagathu C et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006; 17: 4-12
• 23 Miesel R, Hartung R, Kroeger H. Priming of NADPH oxidase by tumor necrosis factor alpha in patients with inflammatory and autoimmune rheumatic diseases. Inflammation 1996; 20: 427-438
• 24 Tlaskalová-Hogenová H, Tucková L, Stepánková R et al. Involvement of innate immunity in the development of inflammatory and autoimmune diseases. Ann N Y Acad Sci 2005; 1051: 787-798
• 25 Li L, Zhang Y, Chen YG et al. Changes of neutrophil myeloperoxidase in coronary circulation among patients with acute coronary syndrome. Zhonghua Xin Xue Guan Bing Za Zhi 2005; 33: 1106-1108
• 26 Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation and cancer. J Clin Invest. 2007; 117: 1175-1183
• 27 Pruchniak MP, Arazna M, Demkow U. Life of neutrophil: from stem cell to neutrophil extracellular trap. Respir Physiol Neurobiol 2013; 187: 68-73
• 28 Stapel SO, Asero R, Ballmer-Weber BK et al. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy 2008; 63: 793-796