Submucosal pedunculated masses of the hypopharynx, larynx, and upper esophagus pose
diagnostic and treatment challenges for gastrointestinal endoscopists. Because of
potentially acute respiratory complications, the removal of these pedunculated masses
through a transoral, transcervical, transthoracic, or endoscopic approach, depending
on their location and size, is mandatory [1].
Inflammatory pseudotumors of the larynx are rare, borderline neoplasms of unknown
etiology and with uncertain malignant potential that often show locally aggressive
behavior [2]. These pedunculated submucosal masses are most commonly approached via endoscopic
excision (dissection of the peduncle by ligature, electrocoagulation, or laser), high
dose steroids, radiation, or surgical excision [3]
[4]
[5].
We report the case of an 81-year-old man, with significant cardiovascular co-morbidities,
who presented with hoarseness, dysphagia, and fatigue that had progressed during the
past 4 years. Upper gastrointestinal endoscopy revealed a giant submucosal mass of
the right vocal fold originating from the right arytenoid cartilage; the pedicle thickness
was 2 cm. Computed tomography showed the mass originating from the larynx ([Fig. 1]) without lymph node involvement.
Fig. 1 Computed tomography reveals a mass originating from the larynx, without lymph node
involvement, in an 81-year-old man presenting with progressive hoarseness, dysphagia,
and fatigue.
The pedunculated mass was removed endoscopically with submucosal dissection followed
by pedicle resection, with a favorable outcome ([Fig. 2], [Video 1]). A transparent cap was attached to a gastroscope. Just below the upper esophageal
sphincter, submucosal dissection was performed with an Olympus DualKnife (Olympus,
Tokyo, Japan), and mucosal hemostasis was achieved with an Olympus Coagrasper. The
dissection was done gradually until complete resection of the pedicle had been achieved;
the total time for dissection was 112 minutes. No significant bleeding or perforation
occurred. Two clips were used to close the esophageal mucosal break.
Fig. 2 a Pedicle thickness of the laryngeal submucosal pedunculated mass. b Endoscopic dissection of the pedicle. c Macroscopic appearance after endoscopic removal.
Giant inflammatory laryngeal pseudotumor removed endoscopically. Initial endoscopic
inspection revealed the laryngeal giant mass, with a thick pedicle, descending into
the esophagus. Submucosal dissection was initiated with a transparent cap just below
the upper esophageal sphincter. Mucosal dissection was done with an Olympus DualKnife,
and mucosal hemostasis was achieved with an Olympus Coagrasper. The dissection was
carried out gradually, layer by layer, until the pedicle had been completely resected.
No significant bleeding occurred. Removal from the esophagus was difficult and was
possible only after partial fragmentation of the mass.
Histological analysis revealed an inflammatory pseudotumor ([Fig. 3]). At 6-month follow-up, the patient’s clinical status was good, without endoscopic
signs of tumor recurrence.
Fig. 3 Microscopic histological analysis (hematoxylin and eosin stain) reveals the presence
of mixed inflammatory cells, mainly leukocytes, and fibrovascular areas with hyalinization.
Giant pedunculated submucosal tumor masses of the larynx can be safely removed endoscopically
in gastrointestinal endoscopy units with submucosal dissection and pedicle resection.
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