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Horm Metab Res 2014; 46(12): 833-840
DOI: 10.1055/s-0034-1389955
Review
© Georg Thieme Verlag KG Stuttgart · New York

Compartmentalization of cAMP Signaling in Adipogenesis, Lipogenesis, and Lipolysis

M. Rogne
1   Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway
2   Biotechnology Centre, University of Oslo, Oslo, Norway
,
K. Taskén
1   Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway
2   Biotechnology Centre, University of Oslo, Oslo, Norway
3   K. G. Jebsen Centre Inflammation Research Centre, University of Oslo, Oslo, Norway
4   K. G. Jebsen Centre for Cancer Immunotherapy, University of Oslo, Oslo, Norway
5   Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway
› Author Affiliations
Further Information

Publication History

received 03 April 2014

accepted 19 August 2014

Publication Date:
23 September 2014 (online)

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Abstract

Energy storage and release at times of food excess or fasting are carefully coordinated processes that depend on the appropriate differentiation of mesenchymal stem cells into mature adipocytes (adipogenesis) forming white adipose tissue (WAT) and on regulatory signals for storage (lipogenesis) or mobilization (lipolysis) of triacylglycerides (TAGs) from lipid droplets. It is widely recognized that cAMP signaling via protein kinase A (PKA) is important both in adipogenesis and for hormonal control and lipolysis in WAT. A kinase anchoring proteins (AKAPs) target PKA to distinct subcellular compartments in close proximity to its specific substrates thereby providing spatial and temporal specificity in the mediation of biological effects controlled by the cAMP-PKA pathway. This review will provide an updated overview of some of the sites of regulation by cAMP in adipogenesis and lipolysis and the involvement of AKAPs and highlighting, as a recent example, the AKAP Optical Atrophy 1 (OPA1) and its role in the phosphorylation of Perilipin to induce lipolysis.

Key words

fat cell - adipose tissue - stem cells
 

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