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Fortschr Neurol Psychiatr 2014; 82(10): 593-605
DOI: 10.1055/s-0034-1385164
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© Georg Thieme Verlag KG Stuttgart · New York

Diagnostik und Therapie von „Freezing of Gait“ bei Patienten mit Morbus Parkinson

Diagnostics and Therapy of “Freezing of Gait” in Patients with Parkinson’s Disease
M. Amarell
1   Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln
,
F. Cepuran
2   UniReha GmbH, Zentrum für Prävention und Rehabilitation, Universitätsklinikum Köln
,
L. Timmermann
1   Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln
,
N. Allert
3   Godeshöhe, Neurologisches Rehabilitationszentrum, Bonn
,
M. T. Barbe
1   Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln
› Author Affiliations
Further Information

Publication History

Publication Date:
09 October 2014 (online)

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Lernziele

  • FOG erkennen

  • Subtypen

  • Diagnostik

  • therapeutische Möglichkeiten

 

  • Literatur

  • 1 Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008; 79: 368-376
    CrossrefPubMedGoogle Scholar
  • 2 Bartels AL, Balash Y, Gurevich T et al. Relationship between freezing of gait (FOG) and other features of Parkinson's: FOG is not correlated with bradykinesia. J Clin Neurosci 2003; 10: 584-588
    CrossrefPubMedGoogle Scholar
  • 3 Giladi N, McDermott MP, Fahn S et al. Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology 2001; 56: 1712-1721
    CrossrefPubMedGoogle Scholar
  • 4 Giladi N, Nieuwboer A. Understanding and treating freezing of gait in parkinsonism, proposed working definition, and setting the stage. Mov Disord 2008; 23 (Suppl. 02) S423-S425
    CrossrefPubMedGoogle Scholar
  • 5 Nutt JG, Bloem BR, Giladi N et al. Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol 2011; 10: 734-744
    CrossrefPubMedGoogle Scholar
  • 6 Snijders AH, Nijkrake MJ, Bakker M et al. Clinimetrics of freezing of gait. Mov Disord 2008; 23 (Suppl. 02) S468-S474
    CrossrefPubMedGoogle Scholar
  • 7 Giladi N, Shabtai H, Rozenberg E et al. Gait festination in Parkinson's disease. Parkinsonism Relat Disord 2001; 7: 135-138
    CrossrefPubMedGoogle Scholar
  • 8 Schaafsma JD, Balash Y, Gurevich T et al. Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's disease. Eur J Neurol 2003; 10: 391-398
    CrossrefPubMedGoogle Scholar
  • 9 Snijders AH, Haaxma CA, Hagen YJ et al. Freezer or non-freezer: clinical assessment of freezing of gait. Parkinsonism Relat Disord 2012; 18: 149-154
    CrossrefPubMedGoogle Scholar
  • 10 Fietzek UM, Zwosta J, Schroeteler FE et al. Levodopa changes the severity of freezing in Parkinson's disease. Parkinsonism Relat Disord 2013; 19: 894-896
    CrossrefPubMedGoogle Scholar
  • 11 Espay AJ, Fasano A, van Nuenen BF et al. On state freezing of gait in Parkinson disease: a paradoxical levodopa-induced complication. Neurology 2012; 78: 454-457
    CrossrefPubMedGoogle Scholar
  • 12 Macht M, Kaussner Y, Möller JC et al. Predictors of freezing in Parkinson's disease: A survey of 6,620 patients. Movement Disorders 2007; 22: 953-956
    CrossrefPubMedGoogle Scholar
  • 13 Giladi N, Treves TA, Simon ES et al. Freezing of gait in patients with advanced Parkinson's disease. J Neural Transm 2001; 108: 53-61
    CrossrefPubMedGoogle Scholar
  • 14 Bloem BR, Hausdorff JM, Visser JE et al. Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena. Mov Disord 2004; 19: 871-884
    CrossrefPubMedGoogle Scholar
  • 15 Gurevich T, Giladi N. Freezing of gait in multiple system atrophy (MSA). Parkinsonism Relat Disord 2003; 9: 169-174
    CrossrefPubMedGoogle Scholar
  • 16 Okuma Y. Practical approach to freezing of gait in Parkinson's disease. Pract Neurol 2014; 14: 222-230
    CrossrefPubMedGoogle Scholar
  • 17 Williams DR, Holton JL, Strand K et al. Pure akinesia with gait freezing: A third clinical phenotype of progressive supranuclear palsy. Movement Disorders 2007; 22: 2235-2241
    CrossrefPubMedGoogle Scholar
  • 18 Magdalinou NK, Ling H, Smith JD et al. Normal pressure hydrocephalus or progressive supranuclear palsy? A clinicopathological case series. J Neurol 2013; 260: 1009-1013
    CrossrefPubMedGoogle Scholar
  • 19 Park HK, Kim JS, Im KC et al. Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses. Movement Disorders 2009; 24: 237-245
    CrossrefPubMedGoogle Scholar
  • 20 Ishihara S, Kano O, Ikeda K et al. Clinicoradiological changes of brain NK/T cell lymphoma manifesting pure akinesia: a case report. BMC Neurol 2011; 11: 137
    CrossrefPubMedGoogle Scholar
  • 21 Giladi N. Freezing of gait. Clinical overview. Adv Neurol 2001; 87: 191-197
    PubMedGoogle Scholar
  • 22 Goetz CG, Tilley BC, Shaftman SR et al. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 2008; 23: 2129-2170
    CrossrefPubMedGoogle Scholar
  • 23 Giladi N, Shabtai H, Simon ES et al. Construction of freezing of gait questionnaire for patients with Parkinsonism. Parkinsonism Relat Disord 2000; 6: 165-170
    CrossrefPubMedGoogle Scholar
  • 24 Giladi N, Tal J, Azulay T et al. Validation of the freezing of gait questionnaire in patients with Parkinson's disease. Mov Disord 2009; 24: 655-661
    CrossrefPubMedGoogle Scholar
  • 25 Barbe MT, Amarell M, Snijders AH et al. Gait and upper limb variability in Parkinson's disease patients with and without freezing of gait. J Neurol 2014; 261: 330-342
    CrossrefPubMedGoogle Scholar
  • 26 Moore ST, Dilda V, Hakim B et al. Validation of 24-hour ambulatory gait assessment in Parkinson's disease with simultaneous video observation. Biomed Eng Online 2011; 10: 82
    CrossrefPubMedGoogle Scholar
  • 27 Chee R, Murphy A, Danoudis M et al. Gait freezing in Parkinson's disease and the stride length sequence effect interaction. Brain 2009; 132: 2151-2160
    CrossrefPubMedGoogle Scholar
  • 28 Iansek R, Huxham F, McGinley J. The sequence effect and gait festination in Parkinson disease: contributors to freezing of gait?. Mov Disord 2006; 21: 1419-1424
    CrossrefPubMedGoogle Scholar
  • 29 Hausdorff JM, Schaafsma JD, Balash Y et al. Impaired regulation of stride variability in Parkinson's disease subjects with freezing of gait. Exp Brain Res 2003; 149: 187-194
    PubMedGoogle Scholar
  • 30 Nanhoe-Mahabier W, Snijders AH, Delval A et al. Walking patterns in Parkinson's disease with and without freezing of gait. Neuroscience 2011; 182: 217-224
    CrossrefPubMedGoogle Scholar
  • 31 Jacobs JV, Nutt JG, Carlson-Kuhta P et al. Knee trembling during freezing of gait represents multiple anticipatory postural adjustments. Exp Neurol 2009; 215: 334-341
    CrossrefPubMedGoogle Scholar
  • 32 Heremans E, Nieuwboer A, Spildooren J et al. Cognitive aspects of freezing of gait in Parkinson's disease: a challenge for rehabilitation. J Neural Transm 2013; 120: 543-557
    CrossrefPubMedGoogle Scholar
  • 33 Vercruysse S, Devos H, Munks L et al. Explaining freezing of gait in Parkinson's disease: motor and cognitive determinants. Mov Disord 2012; 27: 1644-1651
    CrossrefPubMedGoogle Scholar
  • 34 Amboni M, Barone P, Picillo M et al. A two-year follow-up study of executive dysfunctions in parkinsonian patients with freezing of gait at on-state. Mov Disord 2010; 25: 800-802
    CrossrefPubMedGoogle Scholar
  • 35 Cohen RG, Chao A, Nutt JG et al. Freezing of gait is associated with a mismatch between motor imagery and motor execution in narrow doorways, not with failure to judge doorway passability. Neuropsychologia 2011; 49: 3981-3988
    CrossrefPubMedGoogle Scholar
  • 36 Giladi N, Huber-Mahlin V, Herman T et al. Freezing of gait in older adults with high level gait disorders: association with impaired executive function. J Neural Transm 2007; 114: 1349-1353
    CrossrefPubMedGoogle Scholar
  • 37 Nantel J, McDonald JC, Tan S et al. Deficits in visuospatial processing contribute to quantitative measures of freezing of gait in Parkinson's disease. Neuroscience 2012; 221: 151-156
    CrossrefPubMedGoogle Scholar
  • 38 Sunwoo MK, Cho KH, Hong JY et al. Thalamic volume and related visual recognition are associated with freezing of gait in non-demented patients with Parkinson's disease. Parkinsonism Relat Disord 2013; 19: 1106-1109
    CrossrefPubMedGoogle Scholar
  • 39 Herman T, Rosenberg-Katz K, Jacob Y et al. Gray matter atrophy and freezing of gait in Parkinson's disease: Is the evidence black-on-white?. Mov Disord 2014; 29: 134-139
    CrossrefPubMedGoogle Scholar
  • 40 Kostic VS, Agosta F, Pievani M et al. Pattern of brain tissue loss associated with freezing of gait in Parkinson disease. Neurology 2012; 78: 409-416
    CrossrefPubMedGoogle Scholar
  • 41 Tessitore A, Amboni M, Cirillo G et al. Regional gray matter atrophy in patients with Parkinson disease and freezing of gait. AJNR Am J Neuroradiol 2012; 33: 1804-1809
    CrossrefPubMedGoogle Scholar
  • 42 Snijders AH, Leunissen I, Bakker M et al. Gait-related cerebral alterations in patients with Parkinson's disease with freezing of gait. Brain 2011; 134: 59-72
    CrossrefPubMedGoogle Scholar
  • 43 Fling BW, Cohen RG, Mancini M et al. Asymmetric pedunculopontine network connectivity in parkinsonian patients with freezing of gait. Brain 2013; 136: 2405-2418
    CrossrefPubMedGoogle Scholar
  • 44 Youn J, Cho JW, Lee WY et al. Diffusion tensor imaging of freezing of gait in patients with white matter changes. Mov Disord 2012; 27: 760-764
    CrossrefPubMedGoogle Scholar
  • 45 Devos D, Defebvre L, Bordet R. Dopaminergic and non-dopaminergic pharmacological hypotheses for gait disorders in Parkinson's disease. Fundam Clin Pharmacol 2010; 24: 407-421
    CrossrefPubMedGoogle Scholar
  • 46 Ceballos-Baumann AO. Functional imaging in Parkinson's disease: activation studies with PET, fMRI and SPECT. J Neurol 2003; 250 (Suppl. 01) S15-S23
    CrossrefPubMedGoogle Scholar
  • 47 Grafton ST. Contributions of functional imaging to understanding parkinsonian symptoms. Curr Opin Neurobiol 2004; 14: 715-719
    CrossrefPubMedGoogle Scholar
  • 48 Schlesinger I, Erikh I, Yarnitsky D. Paradoxical kinesia at war. Mov Disord 2007; 22: 2394-2397
    CrossrefPubMedGoogle Scholar
  • 49 Snijders AH, Jeene P, Nijkrake MJ et al. Cueing for freezing of gait: a need for 3-dimensional cues?. Neurologist 2012; 18: 404-405
    CrossrefPubMedGoogle Scholar
  • 50 Spildooren J, Vercruysse S, Desloovere K et al. Freezing of gait in Parkinson's disease: the impact of dual-tasking and turning. Mov Disord 2010; 25: 2563-2570
    CrossrefPubMedGoogle Scholar
  • 51 Ambani LM, Van Woert MH. Start hesitation--a side effect of long-term levodopa therapy. N Engl J Med 1973; 288: 1113-1115
    CrossrefPubMedGoogle Scholar
  • 52 Bryant MS, Rintala DH, Hou JG et al. Gait variability in Parkinson's disease: influence of walking speed and dopaminergic treatment. Neurol Res 2011; 33: 959-964
    CrossrefPubMedGoogle Scholar
  • 53 Fahn S, Oakes D, Shoulson I et al. Levodopa and the progression of Parkinson's disease. N Engl J Med 2004; 351: 2498-2508
    CrossrefPubMedGoogle Scholar
  • 54 Shoulson I, Oakes D, Fahn S et al. Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial. Ann Neurol 2002; 51: 604-612
    CrossrefPubMedGoogle Scholar
  • 55 Giladi N. Medical treatment of freezing of gait. Movement Disorders 2008; 23 (Suppl. 02) S482-S488
    CrossrefPubMedGoogle Scholar
  • 56 Pollak L, Dobronevsky Y, Prohorov T et al. Low dose methylphenidate improves freezing in advanced Parkinson's disease during off-state. J Neural Transm Suppl 2007; 145-148
    PubMedGoogle Scholar
  • 57 Devos D, Krystkowiak P, Clement F et al. Improvement of gait by chronic, high doses of methylphenidate in patients with advanced Parkinson's disease. J Neurol Neurosurg Psychiatry 2007; 78: 470-475
    PubMedGoogle Scholar
  • 58 Auriel E, Hausdorff JM, Herman T et al. Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: a pilot study. Clin Neuropharmacol 2006; 29: 15-17
    CrossrefPubMedGoogle Scholar
  • 59 Espay AJ, Dwivedi AK, Payne M et al. Methylphenidate for gait impairment in Parkinson disease: a randomized clinical trial. Neurology 2011; 76: 1256-1262
    CrossrefPubMedGoogle Scholar
  • 60 Moreau C, Delval A, Defebvre L et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. Lancet Neurol 2012; 11: 589-596
    CrossrefPubMedGoogle Scholar
  • 61 Kim YE, Yun JY, Yang HJ et al. Intravenous amantadine for freezing of gait resistant to dopaminergic therapy: a randomized, double-blind, placebo-controlled, cross-over clinical trial. PLoS One 2012; 7: e48890
    CrossrefPubMedGoogle Scholar
  • 62 Lee JY, Oh S, Kim JM et al. Intravenous amantadine on freezing of gait in Parkinson's disease: a randomized controlled trial. J Neurol 2013; 260: 3030-3038
    CrossrefPubMedGoogle Scholar
  • 63 Fukada K, Endo T, Yokoe M et al. L-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson's disease. Med Hypotheses 2013; 80: 209-212
    CrossrefPubMedGoogle Scholar
  • 64 Chung KA, Lobb BM, Nutt JG et al. Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease. Neurology 2010; 75: 1263-1269
    CrossrefPubMedGoogle Scholar
  • 65 Nieuwboer A, Kwakkel G, Rochester L et al. Cueing training in the home improves gait-related mobility in Parkinson's disease: the RESCUE trial. Journal of Neurology, Neurosurgery & Psychiatry 2007; 78: 134-140
    CrossrefPubMedGoogle Scholar
  • 66 Hüter-Becker A, Dölken M, Brüggemann K et al. Physiotherapie in der Neurologie. Stuttgart: Thieme Verlag; 2010
    Article in Thieme ConnectGoogle Scholar
  • 67 Thaut MH, McIntosh GC, Rice RR et al. Rhythmic auditory stimulation in gait training for Parkinson's disease patients. Mov Disord 1996; 11: 193-200
    CrossrefPubMedGoogle Scholar
  • 68 Arias P, Cudeiro J. Effect of Rhythmic Auditory Stimulation on Gait in Parkinsonian Patients with and without Freezing of Gait. PLoS One 2010; 5: e9675
    CrossrefPubMedGoogle Scholar
  • 69 Marchese R, Diverio M, Zucchi F et al. The role of sensory cues in the rehabilitation of parkinsonian patients: a comparison of two physical therapy protocols. Mov Disord 2000; 15: 879-883
    CrossrefPubMedGoogle Scholar
  • 70 Donovan S, Lim C, Diaz N et al. LaserLight cues for gait freezing in Parkinson's disease: An open-label study. Parkinsonism Relat Disord 2011; 17: 240-245
    CrossrefPubMedGoogle Scholar
  • 71 Nieuwboer A, De Weerdt W, Dom R et al. The effect of a home physiotherapy program for persons with Parkinson's disease. J Rehabil Med 2001; 33: 266-272
    CrossrefPubMedGoogle Scholar
  • 72 Nieuwboer A. Cueing for freezing of gait in patients with Parkinson's disease: a rehabilitation perspective. Mov Disord 2008; 23 (Suppl. 02) S475-S481
    CrossrefPubMedGoogle Scholar
  • 73 Ebersbach G, Ebersbach A, Edler D et al. Comparing exercise in Parkinson's disease--the Berlin LSVT(R)BIG study. Mov Disord 2010; 25: 1902-1908
    CrossrefPubMedGoogle Scholar
  • 74 Janssens J, Malfroid K, Nyffeler T et al. Application of LSVT BIG Intervention to Address Gait, Balance, Bed Mobility, and Dexterity in People With Parkinson Disease: A Case Series. Phys Ther 2014; 94: 1014-1023
    CrossrefPubMedGoogle Scholar
  • 75 Duncan RP, Earhart GM. Randomized controlled trial of community-based dancing to modify disease progression in Parkinson disease. Neurorehabil Neural Repair 2011; 26: 132-143
    PubMedGoogle Scholar
  • 76 Volpe D, Signorini M, Marchetto A et al. A comparison of Irish set dancing and exercises for people with Parkinson's disease: a phase II feasibility study. BMC Geriatr 2013; 13: 54
    CrossrefPubMedGoogle Scholar
  • 77 Hong M, Earhart GM. Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations. Parkinsonism Relat Disord 2008; 14: 359-363
    CrossrefPubMedGoogle Scholar
  • 78 Ustinova K, Chernikova L, Bilimenko A et al. Effect of robotic locomotor training in an individual with Parkinson's disease: a case report. Disabil Rehabil Assist Technol 2011; 6: 77-85
    CrossrefPubMedGoogle Scholar
  • 79 Lo AC, Chang VC, Gianfrancesco MA et al. Reduction of freezing of gait in Parkinson's disease by repetitive robot-assisted treadmill training: a pilot study. J Neuroeng Rehabil 2010; 7: 51
    CrossrefPubMedGoogle Scholar
  • 80 Barbe MT, Cepuran F, Amarell M et al. Long-term effect of robot-assisted treadmill walking reduces freezing of gait in Parkinson's disease patients: a pilot study. J Neurol 2013; 260: 296-298
    CrossrefPubMedGoogle Scholar
  • 81 Fisher BE, Li Q, Nacca A et al. Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease. Neuroreport 2013; 24: 509-514
    CrossrefPubMedGoogle Scholar
  • 82 Deuschl G, Schade-Brittinger C, Krack P et al. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med 2006; 355: 896-908
    CrossrefPubMedGoogle Scholar
  • 83 Schuepbach WM, Rau J, Knudsen K et al. Neurostimulation for Parkinson's disease with early motor complications. N Engl J Med 2013; 368: 610-622
    CrossrefPubMedGoogle Scholar
  • 84 Follett KA, Weaver FM, Stern M et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med 2010; 362: 2077-2091
    CrossrefPubMedGoogle Scholar
  • 85 Gervais-Bernard H, Xie-Brustolin J, Mertens P et al. Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: five year follow-up. J Neurol 2009; 256: 225-233
    CrossrefPubMedGoogle Scholar
  • 86 Fasano A, Romito LM, Daniele A et al. Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants. Brain 2010; 133: 2664-2676
    CrossrefPubMedGoogle Scholar
  • 87 Vercruysse S, Vandenberghe W, Munks L et al. Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease: a prospective controlled study. J Neurol Neurosurg Psychiatry 2014; 85: 871-877
    CrossrefPubMedGoogle Scholar
  • 88 Tommasi G, Lopiano L, Zibetti M et al. Freezing and hypokinesia of gait induced by stimulation of the subthalamic region. J Neurol Sci 2007; 258: 99-103
    CrossrefPubMedGoogle Scholar
  • 89 Stolze H, Klebe S, Poepping M et al. Effects of bilateral subthalamic nucleus stimulation on parkinsonian gait. Neurology 2001; 57: 144-146
    CrossrefPubMedGoogle Scholar
  • 90 Rizzone M, Ferrarin M, Pedotti A et al. High-frequency electrical stimulation of the subthalamic nucleus in Parkinson's disease: kinetic and kinematic gait analysis. Neurol Sci 2002; 23 (Suppl. 02) S103-S104
    CrossrefPubMedGoogle Scholar
  • 91 Fasano A, Herzog J, Seifert E et al. Modulation of gait coordination by subthalamic stimulation improves freezing of gait. Mov Disord 2011; 26: 844-851
    CrossrefPubMedGoogle Scholar
  • 92 Niu L, Ji LY, Li JM et al. Effect of bilateral deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease. J Int Med Res 2012; 40: 1108-1113
    CrossrefPubMedGoogle Scholar
  • 93 Moreau C, Defebvre L, Destee A et al. STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology 2008; 71: 80-84
    CrossrefPubMedGoogle Scholar
  • 94 Sidiropoulos C, Walsh R, Meaney C et al. Low-frequency subthalamic nucleus deep brain stimulation for axial symptoms in advanced Parkinson's disease. J Neurol 2013; 260: 2306-2311
    PubMedGoogle Scholar
  • 95 Phibbs FT, Arbogast PG, Davis TL. 60-Hz Frequency Effect on Gait in Parkinson's Disease With Subthalamic Nucleus Deep Brain Stimulation. Neuromodulation 2013; DOI: 10.1111/ner.12131
    PubMedGoogle Scholar
  • 96 Xie T, Kang UJ, Warnke P. Effect of stimulation frequency on immediate freezing of gait in newly activated STN DBS in Parkinson's disease. J Neurol Neurosurg Psychiatry 2012; 83: 1015-1017
    CrossrefPubMedGoogle Scholar
  • 97 Brozova H, Barnaure I, Alterman RL et al. Stn-Dbs Frequency Effects on Freezing of Gait in Advanced Parkinson Disease. Neurology 2009; 72: 770-771
    CrossrefPubMedGoogle Scholar
  • 98 Schrader C, Seehaus F, Capelle HH et al. Effects of Pedunculopontine Area and Pallidal DBS on Gait Ignition in Parkinson's Disease. Brain Stimul 2013; 6: 856-859
    CrossrefPubMedGoogle Scholar
  • 99 Thevathasan W, Coyne TJ, Hyam JA et al. Pedunculopontine nucleus stimulation improves gait freezing in Parkinson disease. Neurosurgery 2011; 69: 1248-1253; discussion 1254
    CrossrefPubMedGoogle Scholar
  • 100 Wilcox RA, Cole MH, Wong D et al. Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait. J Neurol Neurosurg Psychiatry 2011; 82: 1256-1259
    CrossrefPubMedGoogle Scholar
  • 101 Weiss D, Walach M, Meisner C et al. Nigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trial. Brain 2013; 136: 2098-2108
    CrossrefPubMedGoogle Scholar