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Planta Med 2014; 80(17): 1635-1640
DOI: 10.1055/s-0034-1383082
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Bioactive Depsidones from the Fungus Pilobolus heterosporus

Oue-artorn Rajachan
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Somdej Kanokmedhakul
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Kwanjai Kanokmedhakul
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Kasem Soytong
2   Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkutʼs Institute of Technology Ladkrabang, Bangkok, Thailand
› Author Affiliations
Further Information

Publication History

received 24 January 2014
revised 08 August 2014

accepted 18 August 2014

Publication Date:
23 September 2014 (online)

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Abstract

A new aromatic ester, pilobolusate (1), four new depsidones, pilobolusones A–D (2–5), five known depsidones, (6–10), and ergosterol were isolated from the fungus Pilobolus heterosporus. Their structures were established on the basis of spectroscopic data. Compounds 2 and 4–9 showed cytotoxicity against three cancer cell lines (KB, MCF-7, and NCI-H187) with IC50 values in the range of 9.94–97.42 µM. In addition, compounds 2, 5, 9, and 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values ranging from 3.67–23.56 µM.

Key words

Pilobolus heterosporus - Pilobolaceae - depsidone - cytotoxic - antimalarial

Supporting Information

 

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