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Planta Med 2014; 80(11): 942-948
DOI: 10.1055/s-0034-1382838
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Triterpenoid Saponins from the Roots of Clematis argentilucida and Their Cytotoxic Activity

Mei Zhao
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, P. R. China
2   Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xiʼan, P. R. China
,
Ning Ma
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, P. R. China
,
Feng Qiu
3   College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
,
Wen-Li Hai
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, P. R. China
,
Hai-Feng Tang
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, P. R. China
4   Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xiʼan, P. R. China
,
Yan Zhang
2   Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xiʼan, P. R. China
,
Ai-Dong Wen
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, P. R. China
› Author Affiliations
Further Information

Publication History

received 24 March 2014
revised 09 June 2014

accepted 13 June 2014

Publication Date:
16 July 2014 (online)

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Abstract

The reinvestigation of the n-BuOH extract of the roots of Clematis argentilucida led to the isolation of four new oleanane-type triterpenoid saponins, 1–4, four known saponins, 5–8, first isolated from the species, together with ten saponins, 9−18, reported in the preceding papers. The structures of saponins 1–8 were elucidated by extensive spectroscopic analysis and chemical evidences. The cytotoxicity of all the saponins were evaluated against human tumor HL-60, HepG-2, and SGC-7901 cell lines. The monodesmosidic saponins 4, 7, 8, and 14–18 exhibited cytotoxic activity against the three cell lines with IC50 values in the range of 0.87–19.48 µM.

Key words

Clematis argentilucida - Ranunculaceae - triterpenoid saponin - cytotoxicity

Supporting Information

 

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