Zerebello-temporale Konnektivität während visueller Wahrnehmung von Körperbewegungen

Zusammenfassung

Die visuelle Wahrnehmung von Bewegungen unserer Mitmenschen ist in unserem Alltag von großer Bedeutung, sei es beim Autofahren oder bei non-verbaler Kommunikation. Während sich zahlreiche Studien mit dem kortikalen System für visuelle Wahrnehmung von Körperbewegungen beschäftigt haben, blieb der Beitrag subkortikaler Strukturen weitgehend ungeklärt. Ausgehend von ersten Läsionsbefunden bei neurochirurgischen Patienten, die auf die Eloquenz des linken lateralen Kleinhirns hinwiesen, konnten wir mittels funktioneller Magnetresonanztomografie (fMRT) eine Beteiligung der links lateralen zerebellären Läppchen Crus I und VIIB an der visuellen Wahrnehmung von Körperbewegungen zeigen. Dynamic Causal Modelling (DCM) weist auf reziproke effektive Konnektivität zwischen dem linken lateralen Kleinhirn und dem rechten superioren temporalen Sulcus (STS), dem Eckpfeiler des Netzwerks für biologische Bewegungswahrnehmung, hin. Diffusion Tensor Imaging (DTI) liefert erste Hinweise auf eine direkte reziproke Faserbahnverbindung zwischen Kleinhirn und STS. Die Befunde eröffnen neue Perspektiven in der neurologischen und psychiatrischen Forschung.

Abstract

Visual perception of others’ movements is of great value for daily life activities, e. g., for safe car driving or non-verbal communication. While the cortical system for visual perception of body motion has been addressed in a number of studies, the contribution of subcortical structures remains largely unclear. Based on le­sion findings in neurosurgical patients indicating eloquence of the left lateral cerebellum, by using functional magnetic resonance imaging (fMRI), we could demonstrate that the left lateral cerebellar lobules Crus I and VIIB are involved in visual processing of body motion. Dynamic causal modelling (DCM) suggests a reciprocal effective connectivity between the left lateral cerebellum and the right superior temporal sulcus (STS), the cornerstone of the network for biological motion perception. Diffusion tensor imaging (DTI) provides the first evidence for a direct bi­directional fibre pathway between the cerebe­llum and STS. These findings open a new window for future neurological and psychiatric research.

Schlüsselwörter

Kleinhirn - biologische Bewegung - Magnetresonanztomografie (MRT) - Konnektivität - Diffusion Tensor Imaging (DTI)

Key words

cerebellum - biological motion - magnetic resonance imaging (MRI) - connectivity - diffusion tensor imaging (DTI)

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