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Planta Med 2014; 80(08/09): 719-722
DOI: 10.1055/s-0034-1368568
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Coumarins from Toddalia asiatica

Ratchanee Phatchana
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Chavi Yenjai
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
› Author Affiliations
Further Information

Publication History

received 12 June 2013
revised 29 April 2014

accepted 11 May 2014

Publication Date:
17 June 2014 (online)

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Abstract

Three new coumarins and 13 known compounds were isolated from the stem bark of Toddalia asiatica. Compounds 1, 3, 8, and 9 showed cytotoxicity against the NCI-H187 cell line with IC50 values ranging from 6 to 9 µg/mL. Compounds 4 and 9 exhibited cytotoxicity against the MCF-7 cell line with IC50 values of 3.17 and 9.79 µg/mL, respectively. Compound 9 also displayed cytotoxic activity against KB cells with an IC50 value of 8.63 µg/mL. In addition, compound 14 showed antimalarial activity against Plasmodium falciparum with an IC50 value of 3.66 µg/mL. Compounds 5, 9, and 16 exhibited antituberculosis activity against Mycobacterium tuberculosis with MIC values of 50, 50, and 25 µg/mL, respectively.

Key words

Toddalia asiatica - Rutaceae - coumarin - cytotoxicity - antimalarial

Supporting Information

 

  • References

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