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Semin Neurol 2013; 33(05): 498-506
DOI: 10.1055/s-0033-1364215
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Recent Advances in Stroke Recovery and Rehabilitation

Wuwei Feng
2   Department of Neuroscience, MUSC Stroke Center, Charleston, South Carolina
3   Department of Health Science and Research, Center for Rehabilitation Research in Neurological Conditions, Medical University of South Carolina, Charleston, South Carolina
,
Samir R. Belagaje
1   Departments of Neurology and Rehabilitation Medicine, Emory University, Atlanta, Georgia
› Author Affiliations
Further Information

Publication History

Publication Date:
06 February 2014 (online)

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Abstract

Stroke is the fourth leading cause of death in the United States, but remains a leading cause of disability. As more stroke victims survive with advanced acute care, effective strategies and interventions are required to optimize poststroke outcomes. In recent years, knowledge with respect to stroke recovery has expanded greatly through completion of preclinical and clinical trials. Emerging technology may provide further treatment options beyond the standard therapy and practices. In this article, the authors review recent advances in stroke recovery and rehabilitation, including the major determinants of poststroke recovery, challenges in translational stroke recovery research, and several emerging rehabilitation modalities such as noninvasive brain stimulation, brain–computer interface, biotherapeutics, and pharmacologic agents. Potential future directions in research are also addressed.

Keywords

stroke recovery - rehabilitation - determinants - brain stimulation - biotherapeutics
 

  • References

  • 1 Roger VL, Go AS, Lloyd-Jones DM , et al, Heart and stroke statistical update. 2012. Circulation 2012; 125: e2-e220
    CrossrefPubMedGoogle Scholar
  • 2 Towfighi A, Saver JL. Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke 2011; 42 (8) 2351-2355
    CrossrefPubMedGoogle Scholar
  • 3 Taylor TN, Davis PH, Torner JC, Holmes J, Meyer JW, Jacobson MF. Lifetime cost of stroke in the United States. Stroke 1996; 27 (9) 1459-1466
    CrossrefPubMedGoogle Scholar
  • 4 Alberts MJ, Hademenos G, Latchaw RE , et al. Recommendations for the establishment of primary stroke centers. Brain Attack Coalition. JAMA 2000; 283 (23) 3102-3109
    CrossrefPubMedGoogle Scholar
  • 5 Alberts MJ, Latchaw RE, Jagoda A , et al; Brain Attack Coalition. Revised and updated recommendations for the establishment of primary stroke centers: a summary statement from the brain attack coalition. Stroke 2011; 42 (9) 2651-2665
    CrossrefPubMedGoogle Scholar
  • 6 Duncan PW, Zorowitz R, Bates B , et al. Management of adult stroke rehabilitation care: a clinical practice guideline. Stroke 2005; 36 (9) e100-e143
    CrossrefPubMedGoogle Scholar
  • 7 Bates B, Choi JY, Duncan PW , et al; US Department of Defense; Department of Veterans Affairs. Veterans Affairs/Department of Defense Clinical Practice Guideline for the Management of Adult Stroke Rehabilitation Care: executive summary. Stroke 2005; 36 (9) 2049-2056
    CrossrefPubMedGoogle Scholar
  • 8 Duncan PW, Goldstein LB, Matchar D, Divine GW, Feussner J. Measurement of motor recovery after stroke. Outcome assessment and sample size requirements. Stroke 1992; 23 (8) 1084-1089
    CrossrefPubMedGoogle Scholar
  • 9 Prabhakaran S, Zarahn E, Riley C , et al. Inter-individual variability in the capacity for motor recovery after ischemic stroke. Neurorehabil Neural Repair 2008; 22 (1) 64-71
    PubMedGoogle Scholar
  • 10 Hendricks HT, Pasman JW, van Limbeek J, Zwarts MJ. Motor evoked potentials in predicting recovery from upper extremity paralysis after acute stroke. Cerebrovasc Dis 2003; 16 (3) 265-271
    CrossrefPubMedGoogle Scholar
  • 11 Feys H, Van Hees J, Bruyninckx F, Mercelis R, De Weerdt W. Value of somatosensory and motor evoked potentials in predicting arm recovery after a stroke. J Neurol Neurosurg Psychiatry 2000; 68 (3) 323-331
    CrossrefPubMedGoogle Scholar
  • 12 Zarahn E, Alon L, Ryan SL , et al. Prediction of motor recovery using initial impairment and fMRI 48.  h poststroke. Cereb Cortex 2011; 21 (12) 2712-2721
    CrossrefPubMedGoogle Scholar
  • 13 Bushnell CD, Lee J, Duncan PW, Newby LK, Goldstein LB. Impact of comorbidities on ischemic stroke outcomes in women. Stroke 2008; 39 (7) 2138-2140
    CrossrefPubMedGoogle Scholar
  • 14 Fischer U, Arnold M, Nedeltchev K , et al. Impact of comorbidity on ischemic stroke outcome. Acta Neurol Scand 2006; 113 (2) 108-113
    CrossrefPubMedGoogle Scholar
  • 15 Kissela B, Lindsell CJ, Kleindorfer D , et al. Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Stroke 2009; 40 (2) 530-536
    CrossrefPubMedGoogle Scholar
  • 16 Gaete JM, Bogousslavsky J. Post-stroke depression. Expert Rev Neurother 2008; 8 (1) 75-92
    CrossrefPubMedGoogle Scholar
  • 17 Carson AJ, MacHale S, Allen K , et al. Depression after stroke and lesion location: a systematic review. Lancet 2000; 356 (9224) 122-126
    CrossrefPubMedGoogle Scholar
  • 18 Pariente J, Loubinoux I, Carel C , et al. Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol 2001; 50 (6) 718-729
    CrossrefPubMedGoogle Scholar
  • 19 Zittel S, Weiller C, Liepert J. Citalopram improves dexterity in chronic stroke patients. Neurorehabil Neural Repair 2008; 22 (3) 311-314
    PubMedGoogle Scholar
  • 20 Acler M, Robol E, Fiaschi A, Manganotti P. A double blind placebo RCT to investigate the effects of serotonergic modulation on brain excitability and motor recovery in stroke patients. J Neurol 2009; 256 (7) 1152-1158
    CrossrefPubMedGoogle Scholar
  • 21 Chollet F, Tardy J, Albucher JF , et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol 2011; 10 (2) 123-130
    CrossrefPubMedGoogle Scholar
  • 22 Wolf SL, Winstein CJ, Miller JP , et al; EXCITE Investigators. Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA 2006; 296 (17) 2095-2104
    CrossrefPubMedGoogle Scholar
  • 23 Dromerick AW, Lang CE, Birkenmeier RL , et al. Very Early Constraint-Induced Movement during Stroke Rehabilitation (VECTORS): A single-center RCT. Neurology 2009; 73 (3) 195-201
    CrossrefPubMedGoogle Scholar
  • 24 Jongbloed L. Prediction of function after stroke: a critical review. Stroke 1986; 17 (4) 765-776
    CrossrefPubMedGoogle Scholar
  • 25 Nakayama H, Jørgensen HS, Raaschou HO, Olsen TS. The influence of age on stroke outcome. The Copenhagen Stroke Study. Stroke 1994; 25 (4) 808-813
    CrossrefPubMedGoogle Scholar
  • 26 Jørgensen HS, Reith J, Nakayama H, Kammersgaard LP, Raaschou HO, Olsen TS. What determines good recovery in patients with the most severe strokes? The Copenhagen Stroke Study. Stroke 1999; 30 (10) 2008-2012
    CrossrefPubMedGoogle Scholar
  • 27 Bagg S, Pombo AP, Hopman W. Effect of age on functional outcomes after stroke rehabilitation. Stroke 2002; 33 (1) 179-185
    CrossrefPubMedGoogle Scholar
  • 28 Luk JK, Cheung RT, Ho SL, Li L. Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects. Cerebrovasc Dis 2006; 21 (4) 229-234
    CrossrefPubMedGoogle Scholar
  • 29 Denti L, Agosti M, Franceschini M. Outcome predictors of rehabilitation for first stroke in the elderly. Eur J Phys Rehabil Med 2008; 44 (1) 3-11
    PubMedGoogle Scholar
  • 30 Di Carlo A, Lamassa M, Baldereschi M , et al; European BIOMED Study of Stroke Care Group. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke 2003; 34 (5) 1114-1119
    CrossrefPubMedGoogle Scholar
  • 31 Lai SM, Duncan PW, Dew P, Keighley J. Sex differences in stroke recovery. Prev Chronic Dis 2005; 2 (3) A13
    PubMedGoogle Scholar
  • 32 Gargano JW, Reeves MJ ; Paul Coverdell National Acute Stroke Registry Michigan Prototype Investigators. Sex differences in stroke recovery and stroke-specific quality of life: results from a statewide stroke registry. Stroke 2007; 38 (9) 2541-2548
    CrossrefPubMedGoogle Scholar
  • 33 Feng W, Nietert PJ, Adams RJ. Influence of age on racial disparities in stroke admission rates, hospital charges, and outcomes in South Carolina. Stroke 2009; 40 (9) 3096-3101
    CrossrefPubMedGoogle Scholar
  • 34 Jones MR, Horner RD, Edwards LJ , et al. Racial variation in initial stroke severity. Stroke 2000; 31 (3) 563-567
    CrossrefPubMedGoogle Scholar
  • 35 Feng W, Hendry RM, Adams RJ. Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients. Neurology 2010; 74 (7) 588-593
    CrossrefPubMedGoogle Scholar
  • 36 Stansbury JP, Jia H, Williams LS, Vogel WB, Duncan PW. Ethnic disparities in stroke: epidemiology, acute care, and postacute outcomes. Stroke 2005; 36 (2) 374-386
    CrossrefPubMedGoogle Scholar
  • 37 Pearson-Fuhrhop KM, Kleim JA, Cramer SC. Brain plasticity and genetic factors. Top Stroke Rehabil 2009; 16 (4) 282-299
    CrossrefPubMedGoogle Scholar
  • 38 Kleim JA, Chan S, Pringle E , et al. BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. Nat Neurosci 2006; 9 (6) 735-737
    CrossrefPubMedGoogle Scholar
  • 39 Egan MF, Kojima M, Callicott JH , et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112 (2) 257-269
    CrossrefPubMedGoogle Scholar
  • 40 Jiang Y, Wei N, Lu T, Zhu J, Xu G, Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 2011; 172: 398-405
    CrossrefPubMedGoogle Scholar
  • 41 Schäbitz WR, Steigleder T, Cooper-Kuhn CM , et al. Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke 2007; 38 (7) 2165-2172
    CrossrefPubMedGoogle Scholar
  • 42 Fritsch B, Reis J, Martinowich K , et al. Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron 2010; 66 (2) 198-204
    CrossrefPubMedGoogle Scholar
  • 43 Siironen J, Juvela S, Kanarek K, Vilkki J, Hernesniemi J, Lappalainen J. The Met allele of the BDNF Val66Met polymorphism predicts poor outcome among survivors of aneurysmal subarachnoid hemorrhage. Stroke 2007; 38 (10) 2858-2860
    CrossrefPubMedGoogle Scholar
  • 44 Kim JM, Stewart R, Park MS , et al. Associations of BDNF genotype and promoter methylation with acute and long-term stroke outcomes in an East Asian cohort. PLoS ONE 2012; 7 (12) e51280
    CrossrefPubMedGoogle Scholar
  • 45 Martínez-González NA, Sudlow CL. Effects of apolipoprotein E genotype on outcome after ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 2006; 77 (12) 1329-1335
    CrossrefPubMedGoogle Scholar
  • 46 Cramer SC, Procaccio V ; GAIN Americas; GAIN International Study Investigators. Correlation between genetic polymorphisms and stroke recovery: analysis of the GAIN Americas and GAIN International Studies. Eur J Neurol 2012; 19 (5) 718-724
    CrossrefPubMedGoogle Scholar
  • 47 Waters RJ, Nicoll JA. Genetic influences on outcome following acute neurological insults. Curr Opin Crit Care 2005; 11 (2) 105-110
    CrossrefPubMedGoogle Scholar
  • 48 Liepert J, Heller A, Behnisch G, Schoenfeld A. Catechol-O-methyltransferase polymorphism influences outcome after ischemic stroke: a prospective double-blind study. Neurorehabil Neural Repair 2013; 27 (6) 491-496
    PubMedGoogle Scholar
  • 49 Chinnery PF, Elliott HR, Syed A, Rothwell PM ; Oxford Vascular Study. Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study. Lancet Neurol 2010; 9 (5) 498-503
    CrossrefPubMedGoogle Scholar
  • 50 Bernhardt J, Dewey H, Thrift A, Collier J, Donnan G. A Very Early Rehabilitation Trial for Stroke (AVERT): phase II safety and feasibility. Stroke 2008; 39 (2) 390-396
    CrossrefPubMedGoogle Scholar
  • 51 Cumming TB, Thrift AG, Collier JM , et al. Very early mobilization after stroke fast-tracks return to walking: further results from the phase II AVERT randomized controlled trial. Stroke 2011; 42 (1) 153-158
    CrossrefPubMedGoogle Scholar
  • 52 Langhorne P, Stott D, Knight A, Bernhardt J, Barer D, Watkins C. Very early rehabilitation or intensive telemetry after stroke: a pilot randomised trial. Cerebrovasc Dis 2010; 29 (4) 352-360
    CrossrefPubMedGoogle Scholar
  • 53 Huang HC, Chung KC, Lai DC, Sung SF. The impact of timing and dose of rehabilitation delivery on functional recovery of stroke patients. J Chin Med Assoc 2009; 72 (5) 257-264
    CrossrefPubMedGoogle Scholar
  • 54 Cooke EV, Mares K, Clark A, Tallis RC, Pomeroy VM. The effects of increased dose of exercise-based therapies to enhance motor recovery after stroke: a systematic review and meta-analysis. BMC Med 2010; 8: 60
    CrossrefPubMedGoogle Scholar
  • 55 Kozlowski DA, James DC, Schallert T. Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J Neurosci 1996; 16 (15) 4776-4786
    PubMedGoogle Scholar
  • 56 Duncan PW, Sullivan KJ, Behrman AL , et al; LEAPS Investigative Team. Body-weight-supported treadmill rehabilitation after stroke. N Engl J Med 2011; 364 (21) 2026-2036
    CrossrefPubMedGoogle Scholar
  • 57 Lo AC, Guarino PD, Richards LG , et al. Robot-assisted therapy for long-term upper-limb impairment after stroke. N Engl J Med 2010; 362 (19) 1772-1783
    CrossrefPubMedGoogle Scholar
  • 58 Ferbert A, Priori A, Rothwell JC, Day BL, Colebatch JG, Marsden CD. Interhemispheric inhibition of the human motor cortex. J Physiol 1992; 453: 525-546
    CrossrefPubMedGoogle Scholar
  • 59 Perez MA, Cohen LG. Interhemispheric inhibition between primary motor cortices: what have we learned?. J Physiol 2009; 587 (Pt 4) 725-726
    CrossrefPubMedGoogle Scholar
  • 60 Murase N, Duque J, Mazzocchio R, Cohen LG. Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol 2004; 55 (3) 400-409
    CrossrefPubMedGoogle Scholar
  • 61 Hummel F, Celnik P, Giraux P , et al. Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain 2005; 128 (Pt 3) 490-499
    CrossrefPubMedGoogle Scholar
  • 62 Hesse S, Waldner A, Mehrholz J, Tomelleri C, Pohl M, Werner C. Combined transcranial direct current stimulation and robot-assisted arm training in subacute stroke patients: an exploratory, randomized multicenter trial. Neurorehabil Neural Repair 2011; 25 (9) 838-846
    PubMedGoogle Scholar
  • 63 Ameli M, Grefkes C, Kemper F , et al. Differential effects of high-frequency repetitive transcranial magnetic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke. Ann Neurol 2009; 66 (3) 298-309
    CrossrefPubMedGoogle Scholar
  • 64 Fregni F, Boggio PS, Mansur CG , et al. Transcranial direct current stimulation of the unaffected hemisphere in stroke patients. Neuroreport 2005; 16 (14) 1551-1555
    CrossrefPubMedGoogle Scholar
  • 65 Fregni F, Boggio PS, Valle AC , et al. A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients. Stroke 2006; 37 (8) 2115-2122
    CrossrefPubMedGoogle Scholar
  • 66 Dafotakis M, Grefkes C, Eickhoff SB, Karbe H, Fink GR, Nowak DA. Effects of rTMS on grip force control following subcortical stroke. Exp Neurol 2008; 211 (2) 407-412
    CrossrefPubMedGoogle Scholar
  • 67 Lindenberg R, Renga V, Zhu LL, Nair D, Schlaug G. Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patients. Neurology 2010; 75 (24) 2176-2184
    CrossrefPubMedGoogle Scholar
  • 68 Bolognini N, Vallar G, Casati C , et al. Neurophysiological and behavioral effects of tDCS combined with constraint-induced movement therapy in poststroke patients. Neurorehabil Neural Repair 2011; 25 (9) 819-829
    PubMedGoogle Scholar
  • 69 Takeuchi N, Tada T, Toshima M, Matsuo Y, Ikoma K. Repetitive transcranial magnetic stimulation over bilateral hemispheres enhances motor function and training effect of paretic hand in patients after stroke. J Rehabil Med 2009; 41 (13) 1049-1054
    CrossrefPubMedGoogle Scholar
  • 70 Feng WW, Bowden MG, Kautz S. Review of transcranial direct current stimulation in poststroke recovery. Top Stroke Rehabil 2013; 20 (1) 68-77
    CrossrefPubMedGoogle Scholar
  • 71 Yang EJ, Baek SR, Shin J , et al. Effects of transcranial direct current stimulation (tDCS) on post-stroke dysphagia. Restor Neurol Neurosci 2012; 30 (4) 303-311
    PubMedGoogle Scholar
  • 72 Danzl MM, Chelette KC, Lee K, Lykins D, Sawaki L. Brain stimulation paired with novel locomotor training with robotic gait orthosis in chronic stroke: a feasibility study. NeuroRehabilitation 2013; 33 (1) 67-76
    PubMedGoogle Scholar
  • 73 Giacobbe V, Krebs HI, Volpe BT , et al. Transcranial direct current stimulation (tDCS) and robotic practice in chronic stroke: the dimension of timing. NeuroRehabilitation 2013; 33 (1) 49-56
    PubMedGoogle Scholar
  • 74 Khedr EM, Shawky OA, El-Hammady DH , et al. Effect of anodal versus cathodal transcranial direct current stimulation on stroke rehabilitation: a pilot randomized controlled trial. Neurorehabil Neural Repair 2013; 27 (7) 592-601
    PubMedGoogle Scholar
  • 75 Ochi M, Saeki S, Oda T, Matsushima Y, Hachisuka K. Effects of anodal and cathodal transcranial direct current stimulation combined with robotic therapy on severely affected arms in chronic stroke patients. J Rehabil Med 2013; 45 (2) 137-140
    CrossrefPubMedGoogle Scholar
  • 76 Rossi C, Sallustio F, Di Legge S, Stanzione P, Koch G. Transcranial direct current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients. Eur J Neurol 2013; 20 (1) 202-204
    CrossrefPubMedGoogle Scholar
  • 77 Shigematsu T, Fujishima I, Ohno K. Transcranial direct current stimulation improves swallowing function in stroke patients. Neurorehabil Neural Repair 2013; 27 (4) 363-369
    CrossrefPubMedGoogle Scholar
  • 78 Volpato C, Cavinato M, Piccione F, Garzon M, Meneghello F, Birbaumer N. Transcranial direct current stimulation (tDCS) of Broca's area in chronic aphasia: a controlled outcome study. Behav Brain Res 2013; 247: 211-216
    CrossrefPubMedGoogle Scholar
  • 79 Wu D, Qian L, Zorowitz RD, Zhang L, Qu Y, Yuan Y. Effects on decreasing upper-limb poststroke muscle tone using transcranial direct current stimulation: a randomized sham-controlled study. Arch Phys Med Rehabil 2013; 94 (1) 1-8
    CrossrefPubMedGoogle Scholar
  • 80 Available at: www.clinicaltrials.gov . Accessed on August 30, 2013
    PubMed
  • 81 O'Reardon JP, Solvason HB, Janicak PG , et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007; 62 (11) 1208-1216
    CrossrefPubMedGoogle Scholar
  • 82 Lefaucheur JP. Stroke recovery can be enhanced by using repetitive transcranial magnetic stimulation (rTMS). . Neurophysiol Clin 2006; 36 (3) 105-115
    CrossrefPubMedGoogle Scholar
  • 83 Corti M, Patten C, Triggs W. Repetitive transcranial magnetic stimulation of motor cortex after stroke: a focused review. Am J Phys Med Rehabil 2012; 91 (3) 254-270
    CrossrefPubMedGoogle Scholar
  • 84 Yozbatiran N, Alonso-Alonso M, See J , et al. Safety and behavioral effects of high-frequency repetitive transcranial magnetic stimulation in stroke. Stroke 2009; 40 (1) 309-312
    CrossrefPubMedGoogle Scholar
  • 85 Rossi S, Hallett M, Rossini PM, Pascual-Leone A ; Safety of TMS Consensus Group. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 2009; 120 (12) 2008-2039
    CrossrefPubMedGoogle Scholar
  • 86 Edwardson M, Fetz EE, Avery DH. Seizure produced by 20.  Hz transcranial magnetic stimulation during isometric muscle contraction in a healthy subject. Clin Neurophysiol 2011; 122 (11) 2326-2327
    CrossrefPubMedGoogle Scholar
  • 87 Lee B, Liu CY, Apuzzo MLJ. A primer on brain-machine interfaces, concepts, and technology: a key element in the future of functional neurorestoration. World Neurosurg 2013; 79 (3-4) 457-471
    CrossrefPubMedGoogle Scholar
  • 88 Do AH, Wang PT, King CE, Schombs A, Cramer SC, Nenadic Z. Brain-computer interface controlled functional electrical stimulation device for foot drop due to stroke. In: Conference Proceedings of the Annual International Conference of the IEEE Engineering in Medicine & Biology Society. Piscataway, NJ: IEEE; 2012: 6414-6417
    Google Scholar
  • 89 Várkuti B, Guan C, Pan Y , et al. Resting state changes in functional connectivity correlate with movement recovery for BCI and robot-assisted upper-extremity training after stroke. Neurorehabil Neural Repair 2013; 27 (1) 53-62
    PubMedGoogle Scholar
  • 90 Cincotti F, Pichiorri F, Arico P , et al. EEG-based Brain-Computer Interface to support post-stroke motor rehabilitation of the upper limb. In: Conference Proceedings of the Annual International Conference of the IEEE Engineering in Medicine & Biology Society. Piscataway, NJ: IEEE; 2012:4112–4115.
    PubMedGoogle Scholar
  • 91 Bliss T, Guzman R, Daadi M, Steinberg GK. Cell transplantation therapy for stroke. Stroke 2007; 38 (2, Suppl): 817-826
    CrossrefPubMedGoogle Scholar
  • 92 Shyu W-C, Lee Y-J, Liu DD, Lin S-Z, Li H. Homing genes, cell therapy and stroke. Front Biosci 2006; 11: 899-907
    CrossrefPubMedGoogle Scholar
  • 93 Borlongan CV, Hadman M, Sanberg CD, Sanberg PR. Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 2004; 35 (10) 2385-2389
    CrossrefPubMedGoogle Scholar
  • 94 Alvarez-Buylla A, Lim DA. For the long run: maintaining germinal niches in the adult brain. Neuron 2004; 41 (5) 683-686
    CrossrefPubMedGoogle Scholar
  • 95 Luo Y. Cell-based therapy for stroke. J Neural Transm 2011; 118 (1) 61-74
    CrossrefPubMedGoogle Scholar
  • 96 Kolb B, Morshead C, Gonzalez C , et al. Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats. J Cereb Blood Flow Metab 2007; 27 (5) 983-997
    PubMedGoogle Scholar
  • 97 Hong JM, Shin DH, Lim TS, Lee JS, Huh K. Galantamine administration in chronic post-stroke aphasia. J Neurol Neurosurg Psychiatry 2012; 83 (7) 675-680
    CrossrefPubMedGoogle Scholar
  • 98 Berthier ML, Green C, Higueras C, Fernández I, Hinojosa J, Martín MC. A randomized, placebo-controlled study of donepezil in poststroke aphasia. Neurology 2006; 67 (9) 1687-1689
    CrossrefPubMedGoogle Scholar
  • 99 Berthier ML, Green C, Lara JP , et al. Memantine and constraint-induced aphasia therapy in chronic poststroke aphasia. Ann Neurol 2009; 65 (5) 577-585
    CrossrefPubMedGoogle Scholar
  • 100 Gorgoraptis N, Mah Y-H, Machner B , et al. The effects of the dopamine agonist rotigotine on hemispatial neglect following stroke. Brain 2012; 135 (Pt 8) 2478-2491
    CrossrefPubMedGoogle Scholar
  • 101 Kohno N, Abe S, Toyoda G, Oguro H, Bokura H, Yamaguchi S. Successful treatment of post-stroke apathy by the dopamine receptor agonist ropinirole. J Clin Neurosci 2010; 17 (6) 804-806
    CrossrefPubMedGoogle Scholar
  • 102 Bütefisch CM, Davis BC, Sawaki L , et al. Modulation of use-dependent plasticity by d-amphetamine. Ann Neurol 2002; 51 (1) 59-68
    CrossrefPubMedGoogle Scholar
  • 103 Crisostomo EA, Duncan PW, Propst M, Dawson DV, Davis JN. Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients. Ann Neurol 1988; 23 (1) 94-97
    CrossrefPubMedGoogle Scholar
  • 104 Gladstone DJ, Danells CJ, Armesto A , et al; Subacute Therapy with Amphetamine and Rehabilitation for Stroke Study Investigators. Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial. Stroke 2006; 37 (1) 179-185
    CrossrefPubMedGoogle Scholar
  • 105 Martinsson L, Wahlgren NG. Safety of dexamphetamine in acute ischemic stroke: a randomized, double-blind, controlled dose-escalation trial. Stroke 2003; 34 (2) 475-481
    CrossrefPubMedGoogle Scholar
  • 106 Martinsson L, Hårdemark H, Eksborg S. Amphetamines for improving recovery after stroke. Cochrane Database Syst Rev 2007; (1) CD002090
    PubMedGoogle Scholar
  • 107 Winstein CJ, Wolf SL, Dromerick AW , et al; ICARE Investigative Team. Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE): a randomized controlled trial protocol. BMC Neurol 2013; 13: 5
    CrossrefPubMedGoogle Scholar
  • 108 Laver KE, George S, Thomas S, Deutsch JE, Crotty M. Virtual reality for stroke rehabilitation. Cochrane Database Syst Rev 2011; (9) CD008349
    PubMedGoogle Scholar