Effects of n-3 Polyunsaturated Fatty Acids (PUFAs) on Circulating Adiponectin and Leptin in Subjects with Type 2 Diabetes Mellitus

A. Stirban; S. Nandrean; C. Götting; B. Stratmann; D. Tschoepe

doi:10.1055/s-0033-1363225

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2014; 46(07): 490-492
DOI: 10.1055/s-0033-1363225

Endocrine Research

Effects of n-3 Polyunsaturated Fatty Acids (PUFAs) on Circulating Adiponectin and Leptin in Subjects with Type 2 Diabetes Mellitus

A. Stirban

¹Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany

,

S. Nandrean

¹Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany

,

C. Götting

²Institute for Laboratory and Transfusion Medicine of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany

,

B. Stratmann

¹Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany

,

D. Tschoepe

¹Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany

› Author Affiliations

Abstract

Recent evidence suggests that omega-3 polyunsaturated fatty acids [n-3 PUFAs: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], improve insulin sensitivity in humans. In a double-blind, placebo-controlled, randomized, crossover study, we investigated the effects of EPA/DHA on paraoxonase-1 activity as well as fasting and postprandial levels of circulating adiponectin and leptin in 34 subjects with type 2 diabetes mellitus who received daily for 6 weeks either 2 g purified EPA/DHA or olive oil (placebo), separated by a 6 weeks washout. At the end of each treatment, measurements were performed in fasting state and 2, 4, and 6 h following a standardized high-fat meal (600 kcal). No significant differences in fasting and postprandial circulating adiponectin, leptin, and paraoxonase-1 activity were seen between n-3 PUFAs and placebo. Our data do not support an insulin sensitizing effect of n-3 PUFAs by means of influencing circulating adipocytokines in this population. Clinical Trial Register Number: NCT00328536.

Key words

diabetes - n-3 polyunsaturated fatty acids - adiponectin - leptin

Full Text

References

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