Synthesis, Characterization and Antibacterial and Antifungal Evaluation of Some Para-Quinone Derivatives

Abstract

Some novel Pyrrolo [2,3-f] Indole-3,7-Dicarbonitrile derivatives (1–5) were synthesized using chloranil, malononitrile and anilines. The structures of the newly synthesized compounds were characterized by elemental analysis, FT-IR, ¹H- and ¹³C-NMR and mass spectroscopy. These compounds were screened for in vitro antibacterial and antifungal activities against some human pathogenic micro-organisms by employing the disc diffusion technique. Some of the compounds showed moderate to good biological activities when compared with standard drugs.

Key words

quinones - pyrrolo[2,3-f]indole Dicarbonitrile - biological evaluation - synthesis

• References

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