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Planta Med 2014; 80(01): 70-76
DOI: 10.1055/s-0033-1360126
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Enhancement of Doxorubicin Cytotoxicity by Tanshinone IIA in HepG2 Human Hepatoma Cells

Shidong Kan
School of Life Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
,
Wan Man Cheung
School of Life Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
,
Yanling Zhou
School of Life Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
,
Wing Shing Ho
School of Life Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
› Author Affiliations
Further Information

Publication History

received 03 June 2013
revised 10 September 2013

accepted 06 November 2013

Publication Date:
10 January 2014 (online)

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Abstract

Chlorogenic acid (1), salvianolic acid B (2), and tanshinone IIA (3) are commonly used as chemoprotective agents for chemotherapy in cancer patients. The present study deals with the effect of these three compounds on cytotoxicity of doxorubicin in HepG2 cells. The results showed that 1 and 2 reduced the cytotoxicity of doxorubicin through scavenging ROS generated by doxorubicin in HepG2 cells. The findings suggest that 1 and 2 could enhance the expression of SOD and decrease that of NADPH oxidase, which resulted in the elimination of ROS. On the contrary, 3 enhanced the cytotoxicity of doxorubicin in HepG2 cells. Furthermore, drug interactions between doxorubicin and 3 produce synergistic effects in HepG2 cells.

Key words

chemoprotection - chlorogenic acid - salvianolic acid B - tanshinone IIA - doxorubicin - cytotoxicity
 

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