Adoptive Immuntherapie mit dendritischen Zellen

Zusammenfassung

Dendritische Zellen sind professionelle antigenpräsentierende Zellen und spielen eine Schlüsselrolle bei der Induktion und Regulation von Immunantworten. Dendritische Zellen induzieren nicht nur erworbene Immunantworten über die Aktivierung von naiven T- und B-Lymphozyten, sondern kontrollieren Immunität über die Aktivierung von antigenspezifischen T-Regulatorzellen und die Eliminierung von T-Zellen. Bezugnehmend auf ihre Schlüsselrolle im Immunsystem wurden klinische Vakzinierungsstrategien mit dendritischen Zellen in den letzten Jahren kontinuierlich weiterentwickelt und verbessert. In dieser Arbeit werden die wesentlichen Entwicklungen der adoptiven Immuntherapie mit dendritischen Zellen zusammengefasst, welche den klinischen Einsatz voraussichtlich prägen werden.

Key words

dendritische Zellen - Onkologie - Zelltherapie - Vakzinierung - Toleranz

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