Hypothalamic Glucose-sensing: Role of Glia-to-Neuron Signaling

M. C. Tonon; D. Lanfray; H. Castel; H. Vaudry; F. Morin

doi:10.1055/s-0033-1355357

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2013; 45(13): 955-959
DOI: 10.1055/s-0033-1355357

Review

Hypothalamic Glucose-sensing: Role of Glia-to-Neuron Signaling

M. C. Tonon

¹Institut National de la Santé et de la Recherche Médicale (Inserm), Mont-Saint-Aignan, France

²Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, Mont-Saint-Aignan, France

³Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen University, Mont-Saint-Aignan, France

,

D. Lanfray

¹Institut National de la Santé et de la Recherche Médicale (Inserm), Mont-Saint-Aignan, France

²Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, Mont-Saint-Aignan, France

³Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen University, Mont-Saint-Aignan, France

⁴Faculty of Medicine, University Institute of Cardiology and Pneumology of Quebec, University of Laval, Quebec, Canada

,

H. Castel

¹Institut National de la Santé et de la Recherche Médicale (Inserm), Mont-Saint-Aignan, France

²Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, Mont-Saint-Aignan, France

³Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen University, Mont-Saint-Aignan, France

,

H. Vaudry

¹Institut National de la Santé et de la Recherche Médicale (Inserm), Mont-Saint-Aignan, France

²Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, Mont-Saint-Aignan, France

³Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen University, Mont-Saint-Aignan, France

,

F. Morin

¹Institut National de la Santé et de la Recherche Médicale (Inserm), Mont-Saint-Aignan, France

²Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, Mont-Saint-Aignan, France

³Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen University, Mont-Saint-Aignan, France

› Author Affiliations

Abstract

The hypothalamus senses hormones and nutrients in order to regulate energy balance. In particular, detection of hypothalamic glucose levels has been shown to regulate both feeding behavior and peripheral glucose homeostasis, and impairment of this regulatory system is believed to be involved in the development of obesity and diabetes. Several data clearly demonstrate that glial cells are key elements in the perception of glucose, constituting with neurons a “glucose-sensing unit”. Characterization of this interplay between glia and neurons represents an exciting challenge, and will undoubtedly contribute to identify new candidates for therapeutic intervention. The purpose of this review is to summarize the current data that stress the importance of glia in central glucose-sensing. The nature of the glia-to-neuron signaling is discussed, with a special focus on the endozepine ODN, a potent anorexigenic peptide that is highly expressed in hypothalamic glia.

Key words

glial cells - glucose - endozepine

Full Text

References

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