The EuroNet Paediatric Hodgkin Network – Modern Imaging Data Management for Real Time Central Review in Multicentre Trials

L. Kurch; C. Mauz-Körholz; S. Bertling; M. Wallinder; M. Kaminska; D. Marwede; L. Tchavdarova; T. W. Georgi; A. Elsner; A. Barthel; D. Stoevesandt; D. Hasenclever; B. Sattler; O. Sabri; D. Körholz; R. Kluge

doi:10.1055/s-0033-1354416

Klin Padiatr 2013; 225(06): 357-361
DOI: 10.1055/s-0033-1354416

Report

The EuroNet Paediatric Hodgkin Network – Modern Imaging Data Management for Real Time Central Review in Multicentre Trials

Das EuroNet-Paediatric-Hodgkin-Netzwerk – Modernes Bilddatenmanagement innerhalb von multizentrischen Studien mit zentraler Referenzbegutachtung

L. Kurch

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

,

C. Mauz-Körholz

²Department of Paediatrics, Martin-Luther-University Halle/Wittenberg, Halle/Saale, Germany

,

S. Bertling

³Hermes Medical Solutions, Stockholm, Sweden

,

M. Wallinder

³Hermes Medical Solutions, Stockholm, Sweden

,

M. Kaminska

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

,

D. Marwede

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

,

L. Tchavdarova

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

,

T. W. Georgi

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

,

A. Elsner

³Hermes Medical Solutions, Stockholm, Sweden

,

A. Barthel

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

,

D. Stoevesandt

⁴Department of Radiology, Martin-Luther-University Halle/Wittenberg, Halle/Saale, Germany

,

D. Hasenclever

⁵Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany

,

B. Sattler

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

,

O. Sabri

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

,

D. Körholz

²Department of Paediatrics, Martin-Luther-University Halle/Wittenberg, Halle/Saale, Germany

,

R. Kluge

¹Department of Nuclear Medicine, University Hospital of Leipzig, Germany

› Author Affiliations

Abstract

Since 2007, children and adolescents with Hodgkin lymphomas are treated in the Europe-wide EuroNet-PHL trials. A real time central review process for stratification of the patients enhances quality control and efficient therapy management. This process includes reading of all cross-sectional-images. Since reference evaluation is time critical, a fast, easy to handle and safe data transfer is important. In addition, immediate and constant access to all the data has to be guaranteed in case of queries and for regulatory reasons. To meet the mentioned requirements the EuroNet Paediatric Hodgkin Data Network (funded by the European Union – Project Number: 2007108) was established between 2008 and 2011. A respective tailored data protection plan was formulated. The aim of this article is to describe the networks’ mode of operation and the advantages for multi-centre trials that include centralized image review.

Zusammenfassung

Seit 2007 werden Kinder und Jugendlichen, die an einem Hodgkin-Lymphom erkranken innerhalb der europaweit rekrutierenden EuroNet-Studien behandelt. Ein in Echtzeit ablaufender zentraler Referenzprozess zur Stratifizierung der Patienten gewährleistet eine qualitätskontrollierte Behandlung und ein effizientes Therapiemanagement. Dieser Prozess beinhaltet auch die zentrale Referenzbegutachtung der durchgeführten Schnittbildgebungen. Aufgrund der Dringlichkeit ist ein schneller, einfach zu handhabender und sicherer Transport der Bilddaten besonders wichtig. Außerdem muss garantiert sein, dass die Bildgebungen im Fall von Nachfragen ständig verfügbar sind und dass die Datenaufbewahrung den entsprechenden Datenschutzbestimmungen folgt. Um benannte Anforderungen zu erfüllen, wurde im Zeitraum von 2008–2011 das EuroNet-Paediatric-Hodgkin-Datennetzwerk aufgebaut (gefördert von der EU, Projekt-Nr. 2007108). Ein auf das Datennetzwerk zugeschnittener Datenschutzplan wurde erstellt. Ziel dieses Artikels ist, die Funktionsweise des Netzwerkes mit seinen Vorteilen, speziell für Multizenterstudien, die eine Referenzevaluation der Bildgebung vorsehen, zu beschreiben.

Key words

paediatric hodgkin lymphoma - euronet PHL trials - cross sectional imaging - data network - data management - data safety

Schlüsselwörter

Hodgkin-Lymphom im Kindes- und Jugendalter - EuroNet-PHL-Studien - Schnittbildgebung - Bilddatennetzwerk - Bilddatenmanagement - Datensicherheit

Full Text

References

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