Keywords adenoma - pleomorphic - head and neck neoplasms - tongue neoplasms - oropharyngeal
neoplasms
Introduction
Pleomorphic adenoma, also known as mixed tumor , is the most common benign tumor of the major and minor salivary glands.[1 ]
[2 ]
[3 ] Adenoid cystic carcinoma is the most common malignant tumor of this region, including
the tongue.[4 ] The literature indicates an overall ratio of ∼1:6 for benign/malignant lingual salivary
gland tumors.[2 ] More than 74% of the cases of pleomorphic adenoma arise in the major salivary gland,[3 ] and it is predominantly found in the parotid gland. The palate is the most common
site in the minor salivary glands.[5 ] The occurrence of pleomorphic adenoma of the tongue base is very rare and very few
cases have been reported in the literature.[1 ]
[3 ]
The authors report a rare case of pleomorphic adenoma of the tongue base causing dysphagia
and dyspnea and present a review of the literature.
Case Report
A 55-year-old woman presented to the head and neck surgery service complaining of
a cervical mass that had been growing for 3 years. At the moment of presentation,
she had dysphagia, severe dyspnea, and difficulty in talking. She had important pain
and eventual oral bleeding during deglutition. The patient reported smoking 15 cigarettes
(without filter) per day for 30 years. There was no history of alcoholism and no visible
pulsations could be seen in the mass.
Physical examination revealed an ∼8-cm mass in major diameter in the midline at cervical
level I ([Fig. 1 ]). The patient presented lockjaw. Fiberoptic endoscopic examination showed a big
mass at the tongue base with tissue necrosis and a substantial reduction of the airway.
Fig. 1 Patient with an extensive submental mass of a firm elastic consistency.
Magnetic resonance image scan revealed a contrast-enhancing mass of 8 × 8 × 7 cm of
heterogeneous density over the base of the tongue and a reduction of the hypopharyngeal
airway ([Fig. 2 ]).
Fig. 2 Magnetic resonance image: coronal (A) and axial (B) cut showing extensive tumor mass
at the base of the tongue with extension to the hypopharynx and cervical level I.
Biopsy of the lesion was performed along with a tracheostomy due to the bulging tongue
base and acute respiratory failure. A nasoenteral feeding tube was placed.
Histologic examination revealed the possibility that it was a mixed tumor of a malignancy
type of pleomorphic carcinoma ex adenoma, low grade, without a definitive conclusion
due to fragmentation of the material. Immunohistochemically, the cells were positive
for glial fibrillary acid protein, favoring a diagnosis of pleomorphic adenoma.
Subsequently, excision of the mass was performed under general anesthesia using a
lateral pharyngotomy approach, and the total mass was excised with a clear cleavage
plan with the neighboring structures. The histologic examination of the mass confirmed
the diagnosis ([Figs. 3 ] and [4 ]). The postoperative period was uneventful and the patient was successfully decannulated
on the 50th postoperative day and she is free of disease to date.
Fig. 3 Epithelial cells (blue arrow) and myoepithelial cells (yellow arrow; hematoxylin-eosin
stain, original magnification ×400).
Fig. 4 Glial fibrillary acid protein immunoreactivity.
Discussion
The majority of salivary gland neoplasms are benign and pleomorphic adenoma is the
most common. Tumors of the salivary glands comprise 3% of all neoplasms.[4 ] The incidence of salivary gland neoplasms in minor glands varies from 9 to 22%.
Approximately 8% of pleomorphic adenomas involve the minor salivary glands. The majority
involve the palate, followed by the lips and maxillary sinus.[1 ]
[3 ]
[5 ] Involvement of the base of the tongue is rare.[1 ]
[2 ] Malignant tumors such as adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid
carcinoma involve the tongue more frequently.[1 ]
[2 ]
[3 ]
Only 10 other cases of pleomorphic adenoma involving the tongue base have been reported
in the English-language literature ([Table 1 ]). Patients' ages ranged from 24 to 87 years old (average of 49) and the male-to-female
ratio was 3:8, including the present case.
Table 1
Reported cases of pleomorphic adenoma of tongue base
Author(s)
Year
Age (y)
Sex
Size (cm)
Treatment
Goepfert et al[6 ]
1976
39
F
–
Surgery and radiotherapy
Grewal et al[7 ]
1984
35
M
4
Surgery
Deitmer and Stoll[8 ]
1985
29
M
2 × 3
Surgery
Banerjee[9 ]
1987
32
M
2 × 3
Surgery
Magliulo et al[10 ]
1996
82
F
3 × 4
Surgery
Gupta et al[2 ]
1997
50
F
1.75 × 2.5
Surgery
Yoshihara and Suzuki[3 ]
2000
87
F
2 × 3
Surgery
Berry et al[1 ]
2004
66
F
2 × 2
Surgery
Ghosh et al[4 ]
2011
40
F
2 × 2.5
Surgery
Bansal et al[5 ]
2012
24
F
3 × 3
Surgery
Present case
55
F
8 × 8
Surgery
These tumors are slow-growing and sometimes the treatment may be late.[2 ] Dysphagia is the most frequent initial symptom, and some of the tumors are detected
on routine physical examinations by general practitioners.[3 ]
[4 ]
Treatment is primarily surgical irrespective of the site of origin. Resection of the
tumor with an adequate margin is essential to avoid recurrence, although these tumors
are well encapsulated.[1 ] Recurrence is uncommon and may be attributed to partial excision or a multifocal
origin of the tumor.[2 ]
[4 ] Some studies report a recurrence rate of 6% in patients with benign minor salivary
gland tumors.[1 ] Surgical approaches vary according to the size and site of the tumor: transoral,
combined transoral-transcervical, transmandibular, and transpharyngeal. Transmandibular
can be lip splitting, mandibular swing, or median labiomandibular glossotomy. Transpharyngeal
can be either suprahyoid or transhyoid pharyngotomy or by lateral pharyngotomy.[5 ] When the tumor is malignant with extensive invasions into surrounding tissues, the
latter two approaches are recommended.[3 ]
The origin of the pleomorphic adenoma is myoepithelial cells and intercalated duct
cells.[2 ] The histopathologic appearance of a pleomorphic adenoma is mainly composed of epithelial
and myoepithelial elements, with a variety of patterns ending up embedded in mucopolysaccharide
stroma. Fibrosis of the surrounding salivary parenchyma forms a capsule, usually false.[1 ] Pleomorphic adenoma of the minor salivary gland is known to have more cellular and
fewer mesenchymal components. In cases of the elderly, malignant degeneration to carcinoma
ex pleomorphic adenoma must be taken into consideration.[3 ]
Conclusion
This is the 11th case of pleomorphic adenoma involving the tongue base that has been
reported in the English-language literature and the biggest one.
