In Vitro Antiparasitic Activity and Chemical Composition of
                    the Essential Oil Obtained from the Fruits of Piper
                    cubeba

Viviane Rodrigues Esperandim; Daniele da Silva Ferreira; Karen Cristina Sousa Rezende; Lizandra Guidi Magalhães; Julia Medeiros Souza; Patrícia Mendonça Pauletti; Ana Helena Januário; Rosangela da Silva de Laurentz; Jairo Kenupp Bastos; Guilherme Venâncio Símaro; Wilson Roberto Cunha; Márcio Luis Andrade e Silva

doi:10.1055/s-0033-1351022

Planta Medica, Inhaltsverzeichnis

Planta Med 2013; 79(17): 1653-1655
DOI: 10.1055/s-0033-1351022

Biological and Pharmacological Activity

Letters

Georg Thieme Verlag KG Stuttgart · New York

In Vitro Antiparasitic Activity and Chemical Composition of the Essential Oil Obtained from the Fruits of Piper cubeba

Viviane Rodrigues Esperandim

¹University of Franca, Franca, São Paulo, Brazil

,

Daniele da Silva Ferreira

¹University of Franca, Franca, São Paulo, Brazil

,

Karen Cristina Sousa Rezende

¹University of Franca, Franca, São Paulo, Brazil

,

Lizandra Guidi Magalhães

¹University of Franca, Franca, São Paulo, Brazil

,

Julia Medeiros Souza

¹University of Franca, Franca, São Paulo, Brazil

,

Patrícia Mendonça Pauletti

¹University of Franca, Franca, São Paulo, Brazil

,

Ana Helena Januário

¹University of Franca, Franca, São Paulo, Brazil

,

Rosangela da Silva de Laurentz

²College of Engineer of Ilha Solteira (UNESP), Ilha Solteira, São Paulo, Brazil

,

Jairo Kenupp Bastos

³School of Pharmaceutical Sciences of Ribeirão Preto (USP), Ribeirão Preto, São Paulo, Brazil

,

Guilherme Venâncio Símaro

¹University of Franca, Franca, São Paulo, Brazil

,

Wilson Roberto Cunha

¹University of Franca, Franca, São Paulo, Brazil

,

Márcio Luis Andrade e Silva

¹University of Franca, Franca, São Paulo, Brazil

› Institutsangaben

Abstract

Protozoans of the trypanosomatid family cause the neglected tropical diseases leishmaniasis and trypanosomiasis, for which few drugs are available. In this context our group has recently reported that the essential oil obtained by steam distillation of the fruits of Piper cubeba is active against Schistosoma mansoni. Therefore, we have investigated the in vitro effects of the essential oil against the trypomastigote and amastigote forms of Trypanosoma cruzi isolated from an LLCMK₂ cell line culture and the promastigote forms of Leishmania amazonensis. The in vitro activity of the essential oil against trypomastigotes of T. cruzi increased upon rising concentrations, giving IC₅₀ values of 45.5 and 87.9 µg · mL⁻¹ against trypomastigotes and amastigotes, respectively. The essential oil was not active against L. amazonensis, since it displayed lyses of only 24 % at 400 µg · mL⁻¹, and an IC₅₀ of 326.5 µg · mL⁻¹. Therefore, the essential oil should be further investigated to determine the compounds responsible for the observed activities, as well as its mechanism of action.

Key words

Piper cubeba - Piperaceae - essential oil - trypanocidal activity - leishmanicidal activity

Volltext

Referenzen

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